Abstract:

Abstract:Objective
To explore the correlation between the E211 G>A androgen receptor(AR) gene polymorphism and female postadolescent acne of Han Chinese,and lay the foundation for genetic studies of female postadolescent acne of Han Chinese.  Methods The female postadolescent acne patients(n=79) and the healthy people(n=80) were individed into female postadolescent acne group and control group. The polymorphism was investigated by PCR using DNA from peripheral blood lymphocytes. The transition(G>A) in the risk allele(A) produced a new recognition site for the estriction endonuclease StuⅠ. Three genotypes of AR-E211 G>A gene (GG,GA,AA) were determined,and   the differences in the frequencies of the genotype and the allele between female postadolescent acne group and control group were observed. Results There was a significant difference in the frequency of the genotype GA+AA in the AR-E211 genetic polymorphisms between female postadolescent acne patients and healthy control (P=0.028,OR=0.937,OR 95% CI=0.885－0.992);and there was also a significant difference in the allele (A) frequency between female postadolescent acne patients and healthy control (P=－0.029,OR=0.968,OR 95% CI=0.941-0.996).Conclusion The high frequency of A allele in the functional G1733A polymorphism of AR-E211 is a decreased risk factor for female postadolescent acnein Han Chinese.

Key words: androgen receptor;gene polymorphism;female postadolescent acne;han nationality;genetics