Abstract:

Abstract:Objective  To elucidate the genetic association between TNXB gene polymorphisms and schizophrenia in a Han descent population in the north of China.Methods Genomic DNA was isolated from the whole blood samples.A single nucleotide polymorphism,rs204887（Rsa I site） present in the TNXB gene,was detected using PCR-based restriction fragment length polymorphism analysis among 779 Chinese Han patients with schizophrenia and 983 ethnicity-matched healthy controls.The Hardy-Weinberg equilibrium for genotypic distribution was estimated by the goodness-of-fit χ test.The frequencies of alleles and genotypes of TNXB gene and the relationship between allelic frequencies and the clinical phenotypes of schizophrenia were statistically computed.Results The goodness-of-fit χ2 test result showed that the genotypic distributions of rs204887 did not deviate from Hardy-Weinberg equilibrium in both patient group and control group（P>0.05）.The χ test result did not show allelic association and genotypic association for rs204887（P>0.05）.There were no correlations between allelic or genotypic frequencies and the clinical phenotypes of schizophrenia（P>0.05）.Conclusion TNXB locus may not be associated with schizophrenia in a Han descent population in the north of China.

Key words: schizophrenia/genetics； polymorphism, single nucleotide；TNXB