Abstract:

Abstract:Objective Through detecting the expression of dentin matrix protein 1 (C-DMP1) in pleomorphic adenoma and mucoepidermoid carcinoma tissues to investigate the role of expression of C-DMP1 in the oncogenesis of salivary gland tumor.Methods The immunohistochemical method was used to observe the expression of C-DMP1 in 30 cases of benign salivary gland tumor and 30 cases of malignant salivary gland tumors.Results In mucoepidermoid carcinomas,the expression of C-DMP1 in the epidermoid cells was strongly positive,in the nuclei part of the intermediate cells was weakly positive,while the mucous cells were negative,the strongly positive expression rate was 73.3%;In pleomorphic adenoma,part of the nuclei of ductal cells,outer myoepithelial cells and cartilage-like cells were weakly positive,with only a few strongly positive,the strongly positive expression rate was 6.6%.There was significant difference in the stongly positive expression rate of C-DMP1 between benign and malignant tumors in salivary gland (P<0.05).Conclusion The expression of C-DMP1 in the benign and malignant salivary gland tumor tissue  has different changes in its distribution,it suggests that C-DMP1 may participate in the oncogenesis of salivary gland tumor.

Key words: dentin matrix protein 1;pleomorphic adenoma;mucoepidermoid tumor;immunohistochemistry