Abstract:

Abstract:Objective To discuss the value of H-MRS in diagnosis of common intracranial tumors by analyzing the metabolism differences between common intracranial tumors and normal brain tissue,and those among different intracranial tumors with H-MRS.Methods H-MRS manifestations of 27 cases of Ⅰ-Ⅱ grade glioma,22 cases of Ⅲ-Ⅳ grade glioma,24 cases of metastasis and 21 cases of meningioma were analyzed retrospectively,the peak values of N-acetylaspartate(NAA),creatine(Cr),choline(Cho) and lactate(Lac) were detected,the ratios of NAA/Cr,Cho/Cr,and NAA/Cho were compared.Results There were no significant differences among common intracranial tumors in routine MRI examination,and the H-MRS  manifestations of intracranial tumors were obviously  different with that of normal brain tissue:NAA was decreased(P<0.01),Cho was increased(P<0.05),and the NAA/Cr ratio in the region of glioma enhancement was obviously different with those of meningioma and metastasis (P<0.05).Conclusion H-MRS could distinguish differen kinds of intracranial tumors in molecular level,so it can make up  the defect of routine MRI.H-MRS can provide useful image information in intracranial tumors for pathologic classification and regulating  reasonable treatment principles.

Key words: magnetic resonance spectroscopy；chemical shift imaging；field of view