Abstract:

Abstract:Objective To investigate the expressions of CK17 and P63 in cervical cancer tissues,and explore the possibility of CK17 and P63 as markers of cervical cancer stem cells.Methods The expressions of CK17 and P63 in cervical squamous cancer tissues (n=55)　and normal cervix tissues (n=20) were detected with immunohistochemical method.Results ①CK17 expressed in reserve cell cytoplasm in normal cervical specimens.In the cervical cancer specimens,the expression of CK17 was increased and it seemed that CK17 was stained in the margin of the cancer nest and the tumor embolus.In specimens with high grade malignant cancer or after the chemotherapy,the expressions of CK17 were increased（P<0.05）.②P63 was stained in nuclei of reserve cells and almost all cancer cells.Conclusion  CK17 is stained in the margin of the cancer nest and the tumor embolus.In specimens with high grade malignant cancer or after the chemotherapy,the expression of CK17 is increased.CK17 may be the marker of cervical cancer stem cells，but P63 not.

Key words: cervix uter；neoplasms,squamous cell；CK17；P63；neoplastic stem cells