Abstract:

Abstract:Objective To study the relationship between the unbalance of internal environment of blood vessel and obstructive sleep apnea-hypopnea syndrome(OSAHS) compliated with type 2 diabetes and  provide a theoretical basis for protection of the blood vessel  endodermis.Methods 42 patients with OSAHS,38 patients with type 2 diabetes and 32 patients with OSAHS complicated with type  2 diabetes were selected,all the patients  were diagnosed by polysomnography(PSG) and the level of fasting blood sugar.The plasma endothelin(ET-1)and serum nitric oxide(NO) levels were measured by radioimmunoassay and nitrate reductase method respectively.Results The level of plasma ET-1 in patients with OSAHS complicated with type  2 diabetes was higher,the serum NO level and NO/ET-1 were lower than those in the  patients with OSAHS and type 2 diabetes,there were  significant differences (P<0.05).The linear correlation results showed that the plasma ET-1 level was positively  correlated  with the fasting blood sugar(r=0.729),the serum NO level was negatively correlated  with fasting blood sugar(r=－0.586) in the  patients with type 2 diabetes. The plasma ET-1 level was  positively correlated with AHI(r=0.820),the serum NO level was negatively correlated with AHI(r=－0.734) in OSAHS patients.Conclusion The    plasma ET-1 level of patients with OSAHS complicated with type  2 diabetes is higher,the serum NO level and NO/ET-1 are lower than those in  the patients with OSAHS and type 2 diabetes.It demonstrates that the injury of the blood vessel endodermis is more serious  in  patients with OSAHS complicated with type  2 diabetes.

Key words: obstructive sleep apnea-hypopnea syndrome; , endothelin-1;nitric oxide;diabetes mellitus;polysomnography