Abstract:

Abstract:Objective To investigate the effects of Shugan Jieyu Panacea (SJP) on behavior and the levels of ACTH in plasma and T3,T4,TSH,rT3 in serum in depression model rats and explore the mechanism.Methods The model rats were lonely fed and received chronic moderate intensive unpredictable stimulation.Normal  control group,depressed model group,high dosage SJP group,middle dosage SJP group,low dosage SJP group and fluoxetine group were set up.Defferent drugs were used in various groups for 21 d,then the body mass,sugar consumption and the behavior changes of the rats were determined and the levels of ACTH in plasma and T3,T4,TSH,rT3 in serum were detected with radioimmunoassay. Results Compared with normal group,the body mass was  decreased（P<0.01）,the scores of movement and sugar consumption were decreased（P<0.01）in model group. Compared with model group ,the body mass was increased（P<0.01）,the scores of movement and sugar consumption were increased（P<0.01）,the levels of ACTH,T4,rT3 markedly decreased （P<0.05 or P<0.01） and the level of T3 was increased（P<0.05） in high,middle,low dosage SJP groups after treatment. At the same time,there was  no obvious difference between  SJP groups and  fluoxetine groups.Conclusion SJP can significantly improve the depression in rats,its mechanism may be connected with adjusting the function of HPAA and HPTA.

Key words: Shungan Jieju Panacea;depressive disorder;rats,Wistar;adrenocorticotropic hormone;thyrotropin;T3;T4