慢性荨麻疹患者细胞免疫功能检测及其临床意义(附68例报告)

doi:10.13481/j.1671-587x.20180525

Abstract

Abstract: Objective:To study the effect of cellular immune in the pathogenesis of chronic urticaria, and to clarify the immunological mechanism of chronic urticaria. Methods:A total of 68 patients with chronic urticaria and 70 normal controls were selected as the subjects.The patients with chronic urticaria were divided into four different subgroups according to the different complications; there were 11 patients in autoimmune disease group (3 case of rheumatism, 2 case of lupus erythematosus, 4 cases of thyroid diseases, 2 cases vitiligo), 13 patients in Helicobacter pylori infection group, 10 patients in hepatitis B and hepatitis C group, and 6 patients in tumor group. The expressions of T cell surface markers CD3⁺, CD4⁺, and CD8⁺ in the peripheral blood were detected with flow cytometry. Furthermore,the T cell subsets in the peripheral blood of the patients with chronic urticaria with different complications were detected by flow cytometry. Results:Compared with control group, the ratio of CD4⁺ T cells of the patients in chronic urticaria group was significantly decreased (P<0.05), the ratio of CD8⁺ T cells was increased(P<0.05),and the ratio of CD4⁺ T cells/CD8⁺ T cells was decreased (P<0.05);but the ratio of CD3⁺ T cells had no changes (P>0.05).Compared with the patients with the disease duration less than 12 months, the ratio of CD4⁺ T cells of the patients with the disease duration more than 12 months was significantly decreased (P<0.05), the ratio of CD8⁺ T cells was increased(P<0.05),and the ratio of CD4⁺/CD8⁺ was decreased (P<0.05); but the ratio of CD3⁺ T had no changes (P>0.05).Compared with the patients without complications, the ratios of CD4⁺T cells and CD3⁺ T cells of the patients with complications were decreased (P<0.05), the ratio of CD8⁺ T cells was increased(P<0.05),and the ratio of CD4⁺/CD8⁺ was decreased (P<0.05). Conclusion:The unbalance of cellular immune exists in the patients with chronic urticaria, especially the decreasing of the ratio of CD4⁺ T cells in peripheral blood of the patients might be one of the mechanisms of pathogenesis of chronic urticaria.

Key words: chronic urticaria, cellular immunity, humoral immunity, allergic reaction

CLC Number:

R758.24

YAN Tianyi, AN Lin, LI Ping, JIA Yuxi. Detection of cellular immune function in patients with chronic urticaria and its clinical significance:A report of 68 cases[J].Journal of Jilin University(Medicine Edition), 2018, 44(05): 1025-1029.

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Detection of cellular immune function in patients with chronic urticaria and its clinical significance:A report of 68 cases

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