Abstract: Objective:To analyze the clinical diagnosis and treatment and prognosis of the patients with endometrial dedifferentiated carcinoma, and to provide the evidence for its diagnosis and treatment. Methods:The general data, auxiliary examinations,treatment methods and pathological features of 12 patients with endometrial dedifferentiated carcinoma were analyzed retrospectively;literature review was performed,and its diagnosis and treatment methods were analyzed. Results:Among the 12 patients with endometrial dedifferentiated carcinoma, 5 patients in late clinical stage all died, and the average survival time was 10 months;the remaining 7 patients in early clinical stage got a disease-free survival time of 43 months.Twelve patients underwent total hysterectomy, bilateral accessory resection and pelvic lymphadenectomy, of which 2 patients underwent omentectomy and appendectomy, with an average survival time of 8 months; a total of 10 patients remained the omentum majus and appendix, with an average survival time of 24 months.Of the 12 patients, a total of 10 patients received radiotherapy or chemotherapy with an average survival time of 32 months, and 2 patients did not receive the radiotherapy or chemotherapy with an average survival time of 16 months. Conclusion:The patients with endometrial dedifferentiation carcinoma in late clinical stage have shorter survival time and worse prognosis than the patients in early clinical stage.The survival time of patients without chemotherapy or radiotherapy is shorter and the prognosis is worse than those of the patients with chemotherapy or radiotherapy.When the lesion invades omentum majus or appendix,omentectomy and appendectomy are the routine surgical methods for endometrial dedifferentiated carcinoma; resection of the omentum majus or appendix may have no significant effect on the survival time of patient.

Key words: uterine neoplasms, endometrium, dedifferentiated carcinoma, omentectomy, appendicectomy