Abstract: Objective: To explore the relationships between the follicle-stimulating hormone (FSH) level and the lipid profiles in the post-menopausal women, and to provide evidence for assessing the risk of dyslipidemia in the post-menopausal women. Methods: A total of 129 women with menopause for more than 1 year were selected as the subjects and divided into low FSH group(FSH<57.6 IU·L^-1) and high FSH group (FSH ≥ 57.6 IU·L^-1) according to the median of FSH. The data including height, weight, body mass index(BMI), age, menopausal age, duration of menopause, history of smoking, chronic diseases history of the subjects were collected; the serum total cholesterol(TC), triglyceride(TG), low density lipoprotein cholesterol(LDL-C), high density lipoprotein cholesterol(HDL-C), non-density lipoprotein cholesterol(non-HDL-C), estradiol(E2), FSH, fasting blood glucose, serum uric acid of the subjects were detected with the same method. Multivariate Logistic regression analysis was applied to analyze the relationship between the FSH level and dyslipidemia. Results: The average age of the post-menopausal women was (61.22±7.30) years, the age of menopause was (49.97±4.00) years, and the duration of menopause was (11.16±7.98) years. The proportion of post-menopausal women with dyslipidemia was 65.9%(85/129), and there was no significant difference between two groups(P>0.05).Compared with high FSH group, the TG level of the subjects in low FSH group was increased(P<0.01) and the HDL-C level was decreased(P<0.01). There were no significant differences in the TC, LDL-C and non-HDL-C levels between two groups. The Logistic regression analysis showed that after adjusting the E2 level, age, duration of menopause, hypertension history, diabetes history, fatty liver and the BMI grade, FSH level had a negative correlation with TG increase(≥ 2.3mmol·L^-1)(P<0.05). Each 10-unit increase in FSH was associated with a 29.5% lower risk of elevated TG (95%CI: 3.5%-48.5%). FSH was not significantly associated with the elevated TC(≥ 6.2mmol·L^-1), elevated LDL-C(≥ 4.1mmol·L^-1), decreased HDL-C(<1.0 mmol·L^-1) and elevated non-HDL-C. Conclusion: The FSH level is negatively associated with elevated TG inthe post-menopausal women, suggesting that low FSH appears to be a risk factor of dyslipidemia in the post-menopausal women.

Key words: cardiovascular disease, follicle-stimulating hormone, lipid profiles, post-menopause