kartogenin对骨关节炎的治疗作用机制及其在软骨组织工程学中应用的研究进展

doi:10.13481/j.1671-587X.20210235

Abstract

CLC Number:

R684.3

Figures/Tables 1

Tab.1

Nano-scale carriers for carrying KGN and their main characteristics"

Composition	Size by DLS(l/nm)	Surface charge	Carrying method and loading rate	KGN release characteristic	Scaffold	Advantage and feature
RGD-KGN- UCNP@SiO₂ NPs	35	n/a	Conjugated; n/a	More than 50% in 4 h with NIR irradiation	n/a	Long-term tracking of hMSCs by using NIR light； NIR-triggered release of KGN in hMSCs
PN-KGN NPs	25	+	Conjugated; n/a	20% in 30 d	n/a	Promoting electrostatic interactions with cartilage matrix; protecting cartilage for more than 12 weeks after IA injection
PN-KGN NPs	25	+	Conjugated; 13%	11% in 11 d	AMSA/AG hydrogels	Recruiting endogenous MSCs; synergistically enhancing the chondrogenesis of MSCs by loading both KGN and TGF-β3
USPIO-KGN NPs	14±3	n/a	Conjugated; n/a	32% in 6 d	Collagen /cellulose nanocrystals scaffold	Recruiting endogenous MSCs；noninvasively monitoring the sca?olds degradation process and observing the neocartilage regeneration by MRI
USPIO-KGN NPs	14±2（TEM）	n/a	Conjugated; n/a	32% in 6 d	Cellulose nanocrystal/ dextran hydrogels	Recruiting endogenous MSCs; noninvasively monitoring the degradation of hydrogels and neocartilage regeneration in realtime by MRI
F127/COS/ KGN_DCF nanospheres	4 ℃：650； 37 ℃：305	n/a	Conjugated; n/a	20%—50% in 14 d (enhanced with decreasing F127 content )	n/a	Rapid release of DCF for subsidence of inflammation, sustained release of KGN for cartilage regeneration; release enhanced by cold treatment
PGS-KGN nanofibers	617±235（SEM）	n/a	Loaded; n/a	(0.32±0.03) μg·mg^－1(weight of scaffold) in 21 d	PGS/PCL aligned nanofibers	Mimicking structural features of ECM in superficial zone of articular cartilage
HNT/KGN	0.002wt% HNT：235±20；0.005wt% HNT： 219±13	—	Loaded； 6wt%	In PBS：70% in 7 d; In synovial fluid： 100% in 38 d; Hydrogels in PBS：more than 50% in 25 h	HNT/ KGN/ Lap hydrogels	HNT reinforced the rheological properties of the hydrogel;self-repairing after disruption; stable to ultrasound irradiation
PLGA-KGN NPs	270	n/a	Loaded； 7.5wt%	Free : 85% in 60 d; In hydrogels: 70% in 60 d	Acylated HA hydrogels	Recruiting endogenous MSCs；in situ gelation under UV light；sustained release manner
CHI-KGN NPs/ CHI-KGN MPs	NPs: 150±39； MPs: 1840±540	—/+	Conjugated； NPs:（98.1±1.6）%；MPs:（97.9±1.9）%	NPs: 30% in 50 d; MPs: 50% in 50 d	n/a	Sustained release profiles； greater ability for NPs to promote chondrogenic differentiation and cartilage regeneration
PEG-PAMAM- KGN（PPK）/KGN-PEG- PAMAM（KPP）	PPK:36.2±0.2; KPP:33.3±0.4	—/+	Conjugated； PPK:(5.50± 0.2)wt%； KPP:(5.23±0.34)wt%	n/a	n/a	Positive surface charge promoting cellular uptake
PEG-KGN micelles/ HA-PEG-KGN hydrogels	Free： 341.4±58.5；HA hydrogels: 424.7±102.3	n/a	Conjugated; n/a	Micelles:（51.2±5.7）% in 48 h； Hydrogels:（32.4±3.3）% in 5 d	HA hydrogels	Synergistically acting with HA to inhibit the progress of OA

Tab.1

References 41

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Research progress in therapeutic mechanism of kartogenin in osteoarthritis and its application in cartilage tissue engineering

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