Journal of Jilin University(Medicine Edition) ›› 2021, Vol. 47 ›› Issue (4): 1064-1069.doi: 10.13481/j.1671-587X.20210435
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Received:2020-11-18Online:2021-07-28Published:2021-07-22
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Tab.1
Escaping mechanisms of antiviral effects of different viruses on OAS/RNase L pathway"
| Virus | Effects of RNase L on viral replication and/or disease | Virus escape from OAS/ RNASE L systems | Reference |
|---|---|---|---|
| Influenza A virus (IAV) | No effect (cell culture) | NS1 binds dsRNA to inhibit OAS activation | [ |
| Vaccinia virus (VV) | No effect (mice, cell culture) | E3L inhibits OAS activation by binding dsRNA as an inactive 2-5A analogues | [ |
| Human immunodeficiency virus type 1 (HIV-1) | Antiviral and Interferon-α Effects (Cell Culture) | TAT inhibits OAS activation by inhibiting the binding of TAR sequence to OAS protein | [ |
| West Nile virus（WNV） | Antivirus (mice) | Knockout of OAS1b make mice susceptible to WNV and other flaviviruses(FLV) | [ |
| Mouse hepatitis virus (MHV) | NS2 mutants increase virus replication and mortality in RNase L-KO macrophages and mice | NS2 protein encodes PDES to degrade 2-5A | [ |
| Rotavirus A (RVA) | Antiviral | VP3 protein encodes PDES to degrade 2-5A | [ |
| Middle East respiratory syndrome coronavirus (MERS-CoV) | Antiviral | NS4b NS2 protein encodes PDES to degrade 2-5A | [ |
| Transmissible gastroenteritis coronavirus (TGEV) | Antiviral | TGEV protein 7 binds dsRNA to inhibit OAS activation | [ |
| Herpes simplex virus 1(HSV1) | No effect, can’t induce the activation of RNase L in mouse fibroblasts | US11 binds dsRNA to inhibit OAS activation as 2-5A analogues | [ |
| Simian virus 40（SV40） | No effect (cell culture) | Produce inactive 2-5A analogues | [ |
| Poliovirus (PV) | Antiviral | CiRNA inhibite the activity of RNase L | [ |
| Hepatitis C virus (HCV) | Antiviral——Degradation of viral genomes by RNase L | Resistance to RNase L cleavage sites | [ |
| Theiler’s virus | Antiviral | L* directly interacte with the anchor protein domain of RNase L | [ |
| Human immunodeficiency virus type 1 (HIV-1) | Antiviral | Up-regulate RLI and antagonize the binding of RNase L to 2-5A | [ |
| Encephalomyocarditis virus （EMCV） | Antiviral | Up-regulate RLI and antagonize the binding of RNase L to 2-5A | [ |
| Zika virus（ZIKV） | The viral genome is reduced and the titer of viral infection remained unchanged | Early in infection, a protected viral genome library is produced to circumvent RNase L splicing | [ |
Tab.1
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