Abstract:

Objective To study the subtypes of  50 cases of  tonsillar malignant  lymphoma and  the expressions  of Ki-67,bcl-6 and CD10 and explore  their bilolgical significance.Methods By  means of  histomorphology and  immunohistochemistry,50 cases of  primary tonsillar biopsy were reviewed  according to the  new classification of WHO(2008). Results There were 37  cases of   follicular  lymphoma(FL), 9 cases of diffuse large B-cell lymphoma(DLBCL)，2 cases of Burkitt’s lymphoma(BL) and 2 cases of peripheral T-cell lymphoma(PTCL）,16 cases of  FL grade 1 and 2.  The expression of  Ki-67 was in 25%（4/16）  of  the  indolent  lymphoma,and  58.06%（18/31） of the aggressive lymphoma.The Ki-67  expression showed significant difference between different grades of malignancy (P<0.05).The variable expression of bcl-6 was   in  88%(44/50) of  NHL of tonsil.Coexpression of bcl-2+ and bcl-6+  in 40%（8/20）of the low grade FL，61.89%（13/21） of  the high grade FL and 77.78%（7/9）of DLBCL.The CD10 expression showed statistical significance between genders(P<0.05).Conclusion All the cases of tonsillar malignant lymphoma are non-Hodgkins lymphoma.The most histological subtypes is FL,in turn DLBCL,BL and PTCL.There is a rising tendency of Ki-67  expression from low grade FL to aggressive DLBCL.The expressions of bcl-6 vary  in  different  subtypes  such  as  FL，DLBCL，BL  and  PTCL.There  is  an increase trend of bcl-2+ and bcl-6+ coexprssions in low grade FL,high grade FL and DLBCL in sequence.

Key words: malignant lymphoma;tonsillar neoplasms;immunophenotyping