Abstract:

Objective
To discuss the effects of carvedilol on the heart function and glucolipometabolism in elder patients with diastolic heart failure.Methods 76 elder patients with diastolic heart failure were randomly divided into treatment group(n=34) and control group（n=42）,all the patients were given routine treatment of diastolic heart failure,the patients in treatment group were given carvediol in addition( from little dose to more ),the course of treatment was 3-6 months.The parameters of the diastolic function of heart before and after treatment in two groups were determined by ultrasonic cardiogram and uninjured cardiodynamic machine.And the levels of fasting blood glucose,triacylglucerol(TG),cholesterol in two groups were detected.
Results After treatment the total effective rate in treatment group was higher than that in control group( P<0.05).There was no significant difference of blood glucose and lipid between before and after treatment in treatment group.But compared with control group,the levels of blood glucose and lipid in treatment groupo were decreased(P<0.05).During the treatment there was no significant adverse effects in two groups,no stopping treatment.Conclusion Carvedilol could improve the function of left ventricle of elder patients with diastolic heart failure,and has no significant effects on the metabolism of glucose and lipid.

Key words:  carvedilol;diastolic heart failure;elder, glucometabolism;lipid metabolism