In the proliferation function experiment， the HaCaT cells in the logarithmic growth phase were divided into control group and different concentrations （0.011 719， 0.023 438， 0.046 875， 0.093 750， 0.187 500， 0.375 000， 0.750 000 and 1.500 000 mg·L^－1） of Bozhi glycopeptide groups. After the cells were treated for 24h， the CCK-8 method was used to detect the proliferation rates of the cells in various groups to determine the effective concentration of Bozhi glycopeptide. The HaCaT cells in the logarithmic growth phase were divided into control group and different concentrations （0.625， 1.250， 2.500， 5.000， 10.000， 20.000， 40.0000 and 80.000 mg·L^－1） of Bozhi glycopeptide groups. After the cells were treated for 24 and 48 h， the cell proliferation rates in various groups were detected by CCK-8 method. In the adhesion function experiment， the HaCaT cells in the logarithmic growth phase were divided into control group and different concentrations （10 and 20 mg·L^－1） of Bozhi glycopeptide groups. After the cells were treated for 24 and 48 h， the RT-qPCR method was used to detect the expression levels of β-catenin mRNA in the cells in various groups； Western blotting method was used to detect the expression levels of β-catenin protein in the cells in various groups.

In the proliferation function experiment， compared with control group， the cell proliferation rates in 0.011 719－0.093 750 g·L^－1 Bozhi glycopeptide groups were significantly reduced after treated for 24 h（P<0.05）， which was the effective concentration range of Bozhi glycopeptide. Compared with control group，the proliferation rates of cells in 1.250， 2.500，5.000，10.000，20.000，40.000，and 80.000 mg·L^－1 Bozhi glycopeptide groups were significantly reduced after treated for 24 and 48 h（P<0.05 or P<0.01）； the proliferation rate was decreased significantly （P<0.01） when the cells were treated with 20　mg·L^－1 Bozhi glycopeptide for 48 h. In the adhesion function experiment， compared with control group， the expression levels of β-catenin mRNA in the cells in 10 and 20 mg·L^－1 Bozhi glycopeptide groups were decreased significantly after treated for 24 h （P<0.01）， and the expression levels of β-catenin mRNA were decreased significantly after treated for 48 h （P<0.01）. Compared with control group， after 24 h of treatment， the expression level of β-catenin protein in 10 mg·L^－1 Bozhi glycopeptide group was decreased significantly； after 48 h of treatment， the expression levels of β-catenin protein in 10 and 20 mg·L^－1 Bozhi glycopeptide groups tended to increase，but there were no significant differences（P>0.05）.

Bozhi glycopeptide can inhibit the proliferation of KC at a certain concentration and action time， and can inhibit KC adhesion function by reducing the expression of β-catenin. This may be one of the possible mechanisms of Bozhi glycopeptide in the treatment of psoriasis.