羟基磷灰石纳米粒子作为蛋白类缓释药物载体的应用

吉林大学学报(工学版)

羟基磷灰石纳米粒子作为蛋白类缓释
药物载体的应用

滕利荣^a，王博^a，刘艳^a，王春艳^b，孟庆繁^a，高波^a

吉林大学 a.生命科学学院； b.无机合成与制备化学国家重点实验室，长春 130012

收稿日期:2006-11-20 修回日期:1900-01-01 出版日期:2007-09-01 发布日期:2007-09-01
通讯作者: 高波

Protein adsorption onto nanosized hydroxyapatite particles
for controlled drug release

Teng Li-rong^a, Wang Bo^a, Liu Yan^a, Wang Chun-yan^b, Meng Qing-fan^a, Gao Bo^a

a.College of Life Science, Jilin University, Changchun 130012, China； b.State Key Laboratory of Inorganic Synthesis and Preparative Chemistry, Jilin University, Changchun 130012, China

Received:2006-11-20 Revised:1900-01-01 Online:2007-09-01 Published:2007-09-01
Contact: Gao Bo

摘要/Abstract

摘要： 合成了纳米尺寸的羟基磷灰石粒子并对其进行表征，研究了牛血清白蛋白作为模式蛋白对羟基磷灰石纳米粒子的吸附量，探索了影响其吸附的因素（如pH，Ca2+，PO3-3），同时测定了羟基磷灰石纳米粒子牛血清白蛋白复合物的体外释放度。实验结果表明：羟基磷灰石纳米粒子能够作为蛋白类缓释药物的载体。

关键词: 纳米材料, 羟基磷灰石, 牛血清白蛋白, 缓释药物

Abstract: Nanosized hydroxyapatite (nsHAp) was synthesized to examine its possibility as a controlled release carrier of protein. In order to achieve effective protein release from nanosized hydroxyapatite it was necessary to study the adsorptive property of protein on nsHAp and the influence parameters, such as pH, calcium and phosphate, on the adsorption process. Nanosized hydroxyapatite particles were synthesized and characterized. Bovine serum albumin (BSA) was selected as the model protein. Meanwhile, the release kinetics of BSA adsorbed onto the nsHAp (nsHApBSA) was examined. The experiment results show that nanosized hydroxyapatite particles can be successfully used as controlled release carrier of protein.

Key words: nanomaterials, hydroxyapatite, bovine serum albumin, controlled release

中图分类号:

TG156

滕利荣，王博，刘艳，王春艳，孟庆繁，高波 . 羟基磷灰石纳米粒子作为蛋白类缓释
药物载体的应用[J]. 吉林大学学报(工学版), 2007, 37(05): 1093-1096.

Teng Li-rong, Wang Bo, Liu Yan, Wang Chun-yan, Meng Qing-fan, Gao Bo . Protein adsorption onto nanosized hydroxyapatite particles
for controlled drug release[J]. 吉林大学学报(工学版), 2007, 37(05): 1093-1096.

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