牙釉质白垩斑再矿化治疗药物的研究进展

doi:10.13481/j.1671-587X.20260231

吉林大学学报(医学版) ›› 2026, Vol. 52 ›› Issue (2): 572-580.doi: 10.13481/j.1671-587X.20260231

• 综述 • 上一篇

牙釉质白垩斑再矿化治疗药物的研究进展

高伯洋¹,谢尊玄²,刘金瑶¹,何佳洺¹,储顺礼³(),刘玉艳¹()

^1.吉林大学口腔医院牙体牙髓科，吉林长春 130021
^2.吉林大学口腔医院口腔病理科，吉林长春 130021
^3.吉林大学口腔医院口腔种植科，吉林长春 130021

收稿日期:2024-10-27 接受日期:2024-12-11 出版日期:2026-03-28 发布日期:2026-04-15
通讯作者: 储顺礼,刘玉艳 E-mail:chusl@jlu.edu.cn;yuyan@jlu.edu.cn
作者简介:高伯洋（1999-），女，内蒙古自治区锡林郭勒盟人，在读硕士研究生，主要从事牙体牙髓病学方面的研究。
基金资助:
吉林省科技厅科学研究项目(20230203065SF);吉林省教育厅科学研究项目(JJKH20231291KJ)

Research progress in agents for remineralization of white spot lesions

Boyang GAO¹,Zunxuan XIE²,Jinyao LIU¹,Jiaming HE¹,Shunli CHU³(),Yuyan LIU¹()

^1.Department of Endodontics，Stomatology Hospital，Jilin University，Changchun 130021，China
^2.Department of Oral Pathology，Stomatology Hospital，Jilin University，Changchun 130021，China
^3.Department of Dental Implantology，Stomatology Hospital，Jilin University，Changchun 130021，China

Received:2024-10-27 Accepted:2024-12-11 Online:2026-03-28 Published:2026-04-15
Contact: Shunli CHU,Yuyan LIU E-mail:chusl@jlu.edu.cn;yuyan@jlu.edu.cn

摘要/Abstract

摘要：

牙釉质白垩斑（WSLs）是牙釉质因矿物质流失而产生的光学性质改变，表现为白垩样外观，是早期龋病的典型症状。再矿化治疗作为一种非侵入性早期龋损管理方法，通过再矿化药物的应用，诱导矿物质沉积，使部分脱矿的牙体组织重新矿化，从而恢复牙体结构和显微硬度。氟化物能够形成保护性“氟库”并促进氟磷灰石沉积，当氟化物与生物材料或抗菌剂结合时，表现出协同增强矿化修复效果并减少毒性风险的潜力；生物矿化物质还在诱导牙釉质修复和保持生物相容性等方面表现出良好的应用前景。天然成分动植物提取物，能够同时实现牙体硬组织再矿化和口腔微生物控制。现对氟化物、生物矿化物质和动植物提取物等再矿化治疗药物的相关研究进行综述，揭示各类药物的再矿化机制、应用特点、相互作用和治疗效果，为WSLs的再矿化治疗提供科学依据。

关键词: 牙釉质白垩斑, 再矿化, 氟化物, 生物矿化, 植物提取物

Abstract:

White spot lesions （WSLs） represent a change in the optical properties of tooth enamel due to mineral loss， manifesting as a chalky appearance and serving as an early indicator of caries. Remineralization therapy， a non-invasive approach for managing early caries， aims to restore tooth structure and microhardness by inducing mineral deposition through the application of remineralizing agents to remineralize the partially demineralized tooth tissues. Fluoride contributes by forming a protective “fluoride reservoir” and promoting the deposition of fluorapatite； when fluoride is combined with biomaterials or antimicrobial agents， they demonstrate potential to synergistically enhance mineralized restorations while reducing toxicity risks. Biomineralizing substances also show promising applications in inducing enamel repair and maintaining biocompatibility. Additionally， natural ingredients， plant and animal extracts， can effectively synchronize dental hard tissue remineralization with oral microbial control. This review examines various remineralization therapeutic agents， including fluoride， biomineralizing substances， and plant and animal extracts， and elucidates their remineralization mechanisms， application characteristics， interactions， and therapeutic effects. The findings aim to provide a foundation for the remineralization treatment of WSLs.

Key words: White spot lesion, Remineralization, Fluoride, Biomineralization, Plant extract

中图分类号:

R781.2

高伯洋, 谢尊玄, 刘金瑶, 何佳洺, 储顺礼, 刘玉艳. 牙釉质白垩斑再矿化治疗药物的研究进展[J]. 吉林大学学报(医学版), 2026, 52(2): 572-580.

Boyang GAO, Zunxuan XIE, Jinyao LIU, Jiaming HE, Shunli CHU, Yuyan LIU. Research progress in agents for remineralization of white spot lesions[J]. Journal of Jilin University(Medicine Edition), 2026, 52(2): 572-580.

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牙釉质白垩斑再矿化治疗药物的研究进展

Research progress in agents for remineralization of white spot lesions

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