关键词:  , 精神分裂症；小卫星多态性；PLA2G4C基因

Abstract:

Abstract:Objective  To investigate the association between the minisatellite polymorphism in the first exon of PLA2G4C gene and schizophrenia,and to reveal the
important role of DNA sequence polymorphism in the pathogenesis of schizophrenia.Methods The minisatellite polymorphisms in the first exon of PLA2G4C gene in 91 patients with schizophrenia (case group) and 81 healthy persons(control group) were detected with PCR-sequencing analysis.The chi-square (χ2) goodness-of-fit test
 was used to analyze the distribution of  the PLA2G4C minisatellite polymorphism in various groups and to explore the association between the minisatellite polymorphism in
 the first exon of PLA2G4C gene and schizophrenia.Results There were minisatellite polymorphisms in PLA2G4C gene.Three kinds of polymorphisms 1×27 bp，2×27 bp
and 3×27 bp were found by sequencing.The distribution of  allelic frequencies at PLA2G4C polymorphism showed no statistical significance between case group and control group (P>0.05).No statistically significant difference was found in 3-homozygous haplotypes in PLA2G4C gene between case group and control
 group (P>0.05).At the same time,there was no statistically significant difference between 3-heterozygous haplotypes in PLA2G4C gene between case
 group and control group(P>0.05).Conclusion The minisatellite polymorphisms in the first exon of PLA2G4C gene are found,but the minisatellite polymorphism in the first exon of PLA2G4C gene may be not associated with the occurrence of schizophrenia.

Key words: schizophrenia, minisatellite polymorphism, PLA2G4C gene