吉林大学学报(医学版)

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5-羟色胺2A受体基因多态性与精神分裂症遗传关联性的Meta分析

付颖利1,任晓俊2,俞 琼1,史杰萍1,张晴晴1,徐子淇1,于雅琴1,寇长贵1   

  1. 1.吉林大学公共卫生学院流行病与卫生统计学教研室  吉林省分子遗传流行病学重点实
    验室,吉林  长春  130021;2.吉林大学第二医院放疗科,吉林 长春 130041
  • 收稿日期:2013-12-02 出版日期:2014-09-28 发布日期:2014-11-24
  • 通讯作者: 寇长贵(Tel:0431-85619173,E-mail:koucg@jlu.edu.cn); 于雅琴(Tel:0431-85619163,E-mail:yuyaqin5540@163.com) E-mail:koucg@jlu.edu.cn;yuyaqin5540@163.com)
  • 作者简介:付颖利(1987-),女,内蒙古自治区乌兰察布人,在读医学硕士,主要从事慢 性病流行病学研究。
  • 基金资助:

    吉林省卫生计生委科研基金资助课题(2013Z060);卫计委卫生行业科研专项基金资助
    课题 (201202022)

Meta-analysis on inherited association between 5-hydroxytryptamine 
2A receptor gene polymorphism and schizophrenia

FU Ying-li1,REN Xiao-jun2,YU Qiong1,SHI Jie-ping1,ZHANG Qing-qing1,XU Zi-qi1,YU Ya-qin1,KOU Chang-gui1   

  1. 1.Department of  Epidemiology and Health Statistics,School of Public Health,Jilin University, Key Laboratory of   Molecular  Epidemiology,Jilin Province,Changchun 130021,China;2. Department of  Radiotherapy,Second Hospital,Jilin University,Changchun 130041,China
  • Received:2013-12-02 Online:2014-09-28 Published:2014-11-24

摘要:

目的:探讨5-羟色胺2A受体(HTR2A)基因T102C位点多态性与精神分裂症的关联性,
为精神分裂症的遗传背景提供循证医学证据。方法: 计算机检索Pubmed、EMbase、CNKI、
万方医学网和维普数据库,收集2003—2012年有关HTR2A基因T102C多态性与精神分裂症关联
性研究的文献,在全文回顾的基础上对文献进行筛选、评价和数据提取。应用RevMan 5.1
和Stata 12.0软件对纳入的文献进行Meta分析,依据不同种族将研究对象分为欧洲人群和亚洲
人群2个亚组进行分别统计,对等位基因C/T和不同遗传规律基因型CC/TT、CC/CT+TT、CC+CT/T
T及CC+TT/CT共5种模型进行统计,包括异质性检验、合并效应量及评估发表偏倚。结果:
共纳入11个研究,包括2 443例精神分裂症患者和2 469名健康对照者。Meta分析,等位
基因总人群合并OR=1.12,95%CI=0.96~1.31,P>0.05;CC/TT遗传模型总人群合并OR=
1.11,95%CI=0.80~1.53,P>0.05;CC/CT+TT遗传模型总人群合并OR=1.13,95%CI=0.99~1
.30,P>0.05;CC+CT/TT遗传模型总人群合并OR=1.18,95%CI=0.93~1.50,P>0.05;CC+TT/CT
遗传模型总人群合并OR=0.95,95%CI=0.84~1.06,P>0.05。结论:目前的证据不足以表明HTR
2A基因T102C多态性与精神分裂症存在关联性,提示该基因多态性与精神分裂症的遗传无显著关联性。

关键词:  , 精神分裂症;5-羟色胺2A受体;基因多态性;Meta分析

Abstract:

Objective To investigate the association between 5-hydroxytryptamine 2A receptor(HTR2A) gene T102C locus  polymorphism and schizophrenia,and to provide basis for evidence-based medicine for the genetic background of schizophrenia.Methods PubMed,EMbase,CNKI,WanFang and Vip information  databases were used to search full text of all the relevant studies about the association between HTR2A gene T102C locus  polymorphism and schizophrenia,which were published during 2003 to 2012.Based on reviewing full text,the data were selected,evaluated and accessed.RevMan 5.1 and Stata 12.0 were used to perform the statistical analysis of those studies that were in accordance with the inclusive criteria.
According to the different ethnicities,the objects were divided into two subgroups as European and Asian to analyze respectively.Also,depending on different
 inheritances,the  objects were  divided into five patterns including C/T allele,CC/TT,CC/CT+TT,CC+CT/TT and CC+TT/CT genotypes to analyze  respectively,i
ncluding heterogeneity inspection,effect consoliating and publication bias assessment.Results A total of 11 studies were available for this analysis,in
cluding 2 443 schizophrenia patients and 2 469 controls.The Meta-analysis results showed that the allele of all people were OR=1.12,95%CI=0.96-1.31,P>0.05; CC/TT of all people were OR=1.11,95%CI=0.80-1.53,P>0.05;CC/CT+TT of all people were OR=1.13,95%CI=0.99-1.30,P>0.05;CC+CT/TT of all people were OR=1.18,95%CI=0.93-1.50,P>0.05;CC+TT/CT of all people were OR=0.95,95%CI=0.84-1.06,P>0.05.
Conclusion Current evidence is insufficient to show that HTR2A gene T102C locus polymorphism may be associated with schizophrenia,suggesting that the gene polymorphism has no significantly genetic association with schizophrenia.

Key words: schizophrenia, 5-hydroxytryptamine 2A receptor, gene polymorphism, Meta-analysis

中图分类号: 

  • R749.3