关键词:  , 精神分裂症；5-羟色胺2A受体；基因多态性；Meta分析

Abstract:

Objective To investigate the association between 5-hydroxytryptamine 2A receptor(HTR2A) gene T102C locus  polymorphism and schizophrenia,and to provide basis for evidence-based medicine for the genetic background of schizophrenia.Methods PubMed,EMbase,CNKI,WanFang and Vip information  databases were used to search full text of all the relevant studies about the association between HTR2A gene T102C locus  polymorphism and schizophrenia,which were published during 2003 to 2012.Based on reviewing full text,the data were selected,evaluated and accessed.RevMan 5.1 and Stata 12.0 were used to perform the statistical analysis of those studies that were in accordance with the inclusive criteria.
According to the different ethnicities,the objects were divided into two subgroups as European and Asian to analyze respectively.Also,depending on different
 inheritances,the  objects were  divided into five patterns including C/T allele,CC/TT,CC/CT+TT,CC+CT/TT and CC+TT/CT genotypes to analyze  respectively,i
ncluding heterogeneity inspection,effect consoliating and publication bias assessment.Results A total of 11 studies were available for this analysis,in
cluding 2 443 schizophrenia patients and 2 469 controls.The Meta-analysis results showed that the allele of all people were OR=1.12，95%CI=0.96-1.31，P>0.05； CC/TT of all people were OR=1.11，95%CI=0.80-1.53，P>0.05；CC/CT+TT of all people were OR=1.13，95%CI=0.99-1.30，P>0.05；CC+CT/TT of all people were OR=1.18，95%CI=0.93-1.50，P>0.05；CC+TT/CT of all people were OR=0.95，95%CI=0.84-1.06，P>0.05.
Conclusion Current evidence is insufficient to show that HTR2A gene T102C locus polymorphism may be associated with schizophrenia,suggesting that the gene polymorphism has no significantly genetic association with schizophrenia.
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Key words: schizophrenia, 5-hydroxytryptamine 2A receptor, gene polymorphism, Meta-analysis