吉林大学学报(医学版)

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α-catulin和E-cadherin在舌鳞状细胞癌组织中的表达及其临床意义

史 毅1，吴伟忠1，金晓红2，张 斌3   

  1. 1.江苏省丹阳市人民医院口腔科，江苏 丹阳 212300； 2.江苏省丹阳市云阳人民医院
    内科，江苏 丹阳 212300；3.辽宁医学院附属第一医院口腔科，辽宁 锦州 121001
  • 收稿日期:2013-12-05 出版日期:2014-07-28 发布日期:2015-01-18
  • 通讯作者: 张 斌（Tel: 0416-4197262, E-mail: zhangbinjin@sina.com） E-mail: zhangbinjin@sina.com
  • 作者简介:史 毅（1987-），男，江苏省丹阳市人，医学硕士，主要从事口腔颌面 部恶性肿瘤的研究。 
  • 基金资助:

     辽宁省教育厅高等学校科研项目资助课题（L2010315）

Expressions  of α-catulin and E-cadherin in tongue 
squamous cell carcinoma tissue  and clinical significance

SHI Yi1,WU Wei-zhong1,JIN Xiao-hong2, ZHANG Bin3   

  1. 1.Department of Stomatology,Danyang People’s Hospital of Jiangsu Provi nce, Danyang 212300, China; 2.Department of Internal Medicine, Danyang Yunyang People's Hospital of Jiangsu Province, Danyang 212300 China; 3.Department of Stomatology, First Affiliated Hospital, Liaoning Medical College, Jinzhou 121001, China
  • Received:2013-12-05 Online:2014-07-28 Published:2015-01-18

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摘要：

目的：观察舌鳞状细胞癌（TSCC）组织中α-catulin蛋白和上皮-钙黏蛋白（E-cadherin）的表达情况，探讨两者表达与TSCC发生、发展的关系。方法：采用免疫组织化学SP法检测55例TSCC组织和10例正常舌黏膜组织中α-catulin和E-cadherin蛋白的表达，并分析两者在TSCC组织中的表达情况与患者临床病理特征的关系以及两者在TSCC组织中表达的相关性。结果：TSCC和正常舌黏膜组织中α-catulin蛋白阳性表达率分别为69.09%和20.00%，二者比较差异有统计学意义（P<0.01）；α-catulin的表达与TSCC的组织学分化程度、临床分期和颈淋巴结转移均有关联（P<0.05）。在TSCC组织中和正常舌黏膜中E-cadherin蛋白阳性表达率分别为
38.18%和80.00%，二者比较差异有统计学意义（P<0.01）；E-cadherin蛋白阳性表达率与TSCC的临床分期和颈淋巴结转移有关联（P<0.05）。Spearman等级相关分析，TSCC组织中α-catulin与E-cadherin蛋白表达呈负相关关系（r=－0.466，P<0.01）。结论：α-catulin和E-cadherin可能与TSCC的发生和发展密切相关，有望成为临床判断TSCC恶性程度和预后的指标。

关键词: 舌鳞状细胞癌；&alpha, -catulin蛋白；上皮-钙黏蛋白；上皮-间质转化

Abstract:

Abstract:Objective To observe the expressions of α-catulin and E-cadherin in tongue squamous cell carcinoma (TSCC)  tissue,and to explore
 their relationship with the occurrence and development of TSCC.Methods The expressions of α-catulin and E-cadherin in 55 cases of TSCC tissue and 10 cases
 of normal tongue tissue were examined by immunohistochemistry SP method.The relationship between the expressions and the clinicopathological characteristics
 and the relevance of the expressions of α-catulin and E-cadherin in TSCC tissue were analyzed.Results The positive expression rates of α-catulin in TSCC tissue and normal tongue tissue were 69.09% and 20.00%, respectively,and there was   difference between them (P<0.01).The expression of α-catulin was correlated to the histological differentiation,clinical stage and lymph node metastases of TSCC (P<0.05).The positive expression rates of E-cadherin in TSCC tissue and normal tongue tissue were 38.18% and 80.00%, respectively,and there  was significant  difference between them (P<0.01).The expression of E-cadherin was correlated to the clinical stage and lymph node metastases of TSCC ( P<0.05).There was a negative correlation between the expressions of α-catulin and E-cadherin in TSCC tissue（r=－0.466，P<0.01).
Conclusion The expressions of α-catulin and E-cadherin may be associated with the occurrence and development of TSCC,and they could be used as the parameters which predict the malignant degree and prognosis of TSCC.

Key words: tongue squamous cell carcinoma, &alpha, -catulin, E-cadherin, epithelial-mesenchymal transition

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