关键词:  , 肺肿瘤；吸烟；p53基因突变；Meta分析

Abstract:

Objective To evaluate the relationship between smoking and p53 gene mutation in the lung cancer patients with Meta-analysis.
Methods PubMed,Web of Science,ProQest and Medline were used to search all the relevant studies about
 the association between smoking and p53 gene mutation in the patients with lung cancer.Based on reviewing full text,the studies were selected and evaluated and the data was extracted.Statistical analysis was performed with Stata 12.0 software including the heterogeneity inspection,publication bias assessment,sensitivity analysis,effect consolidating and cumulative Meta-analysis.Results Totally 15 articles with 1 770 lung cancer patients were identified. 69.6% of the patients were smokers,30.4% were non-smokers.Overall,the smokers with lung cancer had a 2.70-fold higher risk for p53 gene mutation than the non-smokers with lung cancer (OR=2.70,95%CI=2.04-3.59).Conclusion p53 gene mutation is associated with smoking in the patients with lung cancer.The smokers with lung cancer have higher risk for p53 mutation than non-smokers.

Key words:  , lung neoplasms, smoking, p53 gene mutation, Meta-analysis