吉林大学学报(医学版)

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微血管密度在经直肠超声血流动力学检测鉴别诊断前列腺癌和慢性前列腺炎中的应用及其评价

卢凤迎1,廖新红1,李智贤1,高 泳1,李天宇2   

  1. 1.广西医科大学第一附属医院超声科,广西 南宁 530021;2.广西医科大学第一附属医院泌尿外科,广西 南宁 530021)
  • 收稿日期:2014-01-24 出版日期:2014-09-28 发布日期:2014-11-24
  • 通讯作者: 廖新红(Tel:0771-5356706,E-mail:1016524170@qq.com) E-mail:1016524170@qq.com
  • 作者简介:廖新红(Tel:0771-5356706,E-mail:1016524170@qq.com)
  • 基金资助:

     广西壮族自治区科技厅自然科学基金资助课题(2012GXNSFAA053110)

Application of microvascular density in determination of transrectal ultrasound hemodgynamics in differential diagnosis of prostate cancer and chronic prostatitis

LU Feng-ying1,LIAO Xin-hong1,LI Zhi-xian1,GAO Yong,1LI Tian-yu2   

  1. 1.Department of Ultrasonography,First Affiliated Hospital,Guangxi Medical University,Nanning,530021,China;2.Department of Urinary,First Affiliated Hospital,Guangxi Medical University,Naning 530021,China
  • Received:2014-01-24 Online:2014-09-28 Published:2014-11-24

摘要:

目的:探讨微血管密度(MVD)在经直肠超声血流动力学检测鉴别诊断前列腺癌和慢性前列腺炎中的应用价值,为二者的鉴别诊断提供影像学依据。方法:共收集61例临床疑为前列腺癌患者,均经直肠超声扫查及超声引导下穿刺活检,病理证实38例前列腺癌和23例慢性前列腺炎,分组进行病例回顾性分析,对2组患者前列腺可疑病灶动脉收缩期峰值血流速度(Vs)和血运分级进行对比分析。对前列腺活检组织用CD34免疫组织化学染色后采用Weinder方法测定MVD。结果:前列腺癌组患者可疑病灶Vs和血运分级明显高于慢性前列腺炎组(P<0.05)。前列腺癌组和慢性前列腺炎组MVD分别为46.70±13.87和34.38±7.28(P<0.05)。前列腺癌(C+D)期和(A+B)期组MVD分别为56.99±12.85和39.97±10.21(P<0.05);前列腺癌Gleason评分≥7 分 的Gleason高评分组和<7 分的Gleason低评分组MVD分别为53.79±13.30和36.96±7.24(P<0.05)。前列腺癌可疑病灶Vs及血运分级与前列腺癌组织MVD呈显著正相关关系(r=0.793,P<0.05;r=0.723,P<0.05
)。结论:超声影像显示的前列腺癌Vs和血运分级能较好地反映肿瘤组织内微血管的变化,且前列腺癌患者可疑病灶或血流丰富区Vs及血运分级明显高于慢性前列腺炎患者;Vs和血运分级可作为前列腺癌和慢性前列腺炎鉴别诊断的有用指标。

关键词:  , 前列腺肿瘤, 慢性前列腺炎;超声血流动力学;微血管密度

Abstract:

Objective To study the application value of microvascular density(MVD) in determination of transrectal ultrasound hemodgynamics in the differential diagnosis of prostate cancer and chronic prostatitis,and to provide imageological basis for their differential diagnosis.Methods A total of 61 patients suspected of  prostate cancer underwent transrectal ultrasound scan and ultra
sound guided biopsy.38 cases of prostate cancer and 23 cases of chronic prostatitis were confirmed by pathology and retrospectively analyzed.The peak systolic blood flow velocity (Vs)  and blood flow classification of the  suspicious lesions were compared and analyzed.The MVD was observed by Weidner method with monoclonal antibody CD34 immunohisochemistry staning.Results The Vs and the blood flow classification of the suspicious lesions in  prostate cancer group were significant higher than those in chronic prostatitis group  (P<0.05).The MVD in prostate cancer group and chronic prostatitis group were 46.70±13.87 and 34.38±7.28,respectively(P<0.05);the MVD in prostate cancer (C+D)stage and (A+B)stage were 56.99±12.85 and 39.97±10.21,respectively(P<0.05);the MVD in prostate cancer with high Gleason score group and low Gleason score group were 53.79±13.30 and 36.96±7.24,respectively(P<0.05).The Vs and the blood flow classification of the suspicious lesions of prostate cancer had a significantly positive correlation with the MVD (r=0.793,P<0.05;r=0.723,P<0.05).Conclusion The Vs and the blood flowclassification of prostate cancer by ultrasound can well reflect the changes of the micrangium in tumor tissue.The  Vs and blood supply grade of suspicious lesions in the patients with prostate cancer are significantly higher than those in the patients with chronic prostatitis.They may be useful for the identification of prostate cancer and chronic prostatitis.

Key words: prostate neoplasms, chronic prostatitis, ultrasonic hemodgynamics, microvascular density

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