关键词: 多中心胶质瘤, 病例报告, 多中心少突星形细胞瘤, 少突星形细胞瘤, 多灶性胶质瘤

Abstract: Objective:To report the clinical manifestations of 1 case of intracranial multicentric astrocytoma, and to provide a reference for its clinical diagnosis and treatment. Methods: The clinical data of one patient with intracranial multicentric astrocytomas were retrospectively analyzed and the diagnosis and treatment were summarized, and the relevant literatures were reviewed. Results: The patient was male, 25 years old,and admitted to hospital due to the sudden convulsions 1 time 18 d ago. The head MRI scanning and enhanced scanning displayed that the left frontal lobe and corpus callosum knee exited the group of patchy mixed abnormal signals, and the left frontal temporal lobe exited the capsule-like mixed signals. Surgical treatment was performed, and the lesions of the left frontal lobe and corpus callosum knee and left frontal temporal lobe were resected. The difference of the two lesions was observed during the operation (the left frontal and corpus callosum knee lesion was cystic and solid mixed tissue, solid organization accounted for majority, and had internal calcification; the left frontal temporal lobe lesion was cystic and solid mixed tissue, and cystic tissue accounted for the majority). The postoperative pathology showed that the left frontal lobe and corpus callosum knee lesion had locally more intensive cells, and more different cells, and it was diagnosed as astrocytoma (WHO Ⅱ-Ⅲ); the left frontal temporal lobe lesion was diagnosed as astrocytoma (WHO Ⅱ). After operation, the patient recovered well, and it was recommended to continue radiotherapy and chemotherapy. Conclusion: For the patients with intracranial multicentric astrocytomas, active surgical treatment is in favor of prolonging the survival of the patients. Postoperative radiotherapy is still controversial, but chemotherapy should be recommended.

Key words: multicentric astrocytoma, case report, multicentric glioma, multifocal cerebral glioma, astrocytoma