[1] Singer M,Deutschman CS,Seymour CW,et al. The third international consensus definitions for sepsis and septic shock (sepsis-3)[J].JAMA,2016,315(8):801-810. [2] Martin GS,Mannino DM,Eaton S,et al.The epidemiology of sepsis in the United States from 1979 through 2000[J].N Engl J Med,2003,348(16):1546-1554. [3] HassDT,Barnstable CJ.Uncoupling protein 2 in the glial response to stress:implications for neuroprotection[J].Neural Regen Res,2016,11(8):1197-1200. [4] Jun Z,Ibrahim MM,Dezheng G,et al.UCP2 protects against amyloid beta toxicity and oxidative stress in primary neuronal culture[J].Biomed Pharmacother,2015,74:211-214. [5] Jiang ZM,Yang QH,Zhu CQ.UCP2 in early diagnosis and prognosis of sepsis[J].Eur Rev Med Pharmacol Sci,2017,21(3):549-553. [6] Zheng G,Lyu J,Liu S,et al.Silencing of uncoupling protein 2 by small interfering RNA aggravates mitochondrial dysfunction in cardiomyocytes under septic conditions[J].Int J Mol Med,2015,35(6):1525-1536. [7] Hartman ME,Linde-Zwirble WT,Angus DC,et al.Trends in the epidemiology of pediatric severe sepsis*[J].Pediatr Crit Care Med,2013,14(7):686-693. [8] Romero-Bermejo FJ,Ruiz-Bailen M,Gil-Cebrian J,et al.Sepsis-induced cardiomyopathy[J].Curr Cardiol Rev,2011,7(3):163-183. [9] Lowes DA,Almawash AM,Webster NR,et al.Melatonin and structurally similar compounds have differing effects on inflammation and mitochondrial function in endothelial cells under conditions mimicking sepsis*[J].Br J Anaesth,2011,107(2):193-201. [10] Pathak E,Mayeux PR.In vitro model of sepsis-induced renal epithelial reactive nitrogen species generation[J].Toxicol Sci,2010,115(2):475-481. [11] Lowes DA,Thottakam BM,Webster NR,et al.The mitochondria-targeted antioxidant MitoQ protects against organ damage in a lipopolysaccharide-peptidoglycan model of sepsis[J].Free Radic Biol Med,2008,45(11):1559-1565. [12] Kizaki T,Suzuki K,Hitomi Y,et al.Uncoupling protein 2 plays an important role in nitric oxide production of lipopolysaccharide-stimulated macrophages[J].Proc Natl Acad Sci USA,2002,99(14):9392-9397. [13] Blanc J,Alves-Guerra MC,Esposito B,et al.Protective role of uncoupling protein 2 in atherosclerosis[J].Circulation,2003,107(3):388-390. [14] Nègre-Salvayre A,Hirtz C,Carrera G,et al.A role for uncoupling protein-2 as a regulator of mitochondrial hydrogen peroxide generation[J].ASEB J,1997,11(10):809-815. [15] Andrews ZB,Diano S,Horvath TL.Mitochondrial uncoupling proteins in the CNS:in support of function and survival[J].Nat Rev Neurosci,2005,6(11):829-840. [16] Andrews ZB,Liu ZW,Walllingford N,et al.UCP2 mediates ghrelin's action on NPY/AgRP neurons by lowering free radicals[J].Nature,2008,454(7206):846-851. [17] Parton LE,Ye CP,Coppari R,et al.Glucose sensing by POMC neurons regulates glucose homeostasis and is impaired in obesity[J].Nature,2007,449(7159):228-232. [18] Welty-Wolf KE,Simonson SG,Huang YC,et al.Ultrastructural changes in skeletal muscle mitochondria in gram-negative sepsis[J].Shock,1996,5(5):378-384. [19] Vanhorebeek I,De Vos R,Mesotten D,et al.Protection of hepatocyte mitochondrial ultrastructure and function by strict blood glucose control with insulin in critically ill patients[J].Lancet,2005,365(9453):53-59. [20] CrouserED,Julian MW,Dorinsky PM,et al.VO(2)-O(2) alterations induced by endotoxin correlate with severity of mitochondrial injury[J].Am J Respir Crit Care Med,1999,160(4):1347-1353. [21] Soriano FG,Nogueira AC,Caldini EG,et al.Potential role of poly(adenosine 5'-diphosphate-ribose) polymerase activation in the pathogenesis of myocardial contractile dysfunction associated with human septic shock[J].Crit Care Med,2006,34(4):1073-1079. [22] Kwok KH,Ho PW,Chu AC,et al.Mitochondrial UCP5 is neuroprotective by preserving mitochondrial membrane potential,ATP levels,and reducing oxidative stress in MPP+ and dopamine toxicity[J].Free Radic Biol Med,2010,49(6):1023-1035. [23] Pak O,Sommer N,Hoeres T,et al.Mitochondrial hyperpolarization in pulmonary vascular remodeling.Mitochondrial uncoupling protein deficiency as disease model[J].Am J Respir Cell Mol Biol,2013,49(3):358-367. [24] Baines CP,Song CX,Zheng YT,et al.Protein kinase Cepsilon interacts with and inhibits the permeability transition pore in cardiac mitochondria[J].Circ Res,2003,92(8):873-880. |