复杂性区域疼痛综合征治疗的研究进展

doi:10.13481/j.1671-587x.20180538

摘要/Abstract

摘要： 复杂性区域疼痛综合征（CRPS）是发生于身体局部区域的疼痛综合征，可伴发感觉、运动、自主神经、皮肤和骨的异常改变。该病的发病机制尚未明确，目前国际上对该病的诊断主要是根据患者局部异常性疼痛及相关症状和体征。综合现阶段的研究，跨学科的疼痛管理是较为提倡的治疗方式，包括药物治疗、康复治疗和手术介入治疗等。药物治疗包括骨吸收抑制剂（二磷酸盐）、免疫球蛋白、N-甲基-D-天冬氨酸受体拮抗剂（氯胺酮）和抗癫痫药物等，在缓解疼痛方面有较好的疗效，维生素C可以通过抗氧化抑制炎性反应，被推荐为预防用药。在康复治疗中，经颅磁刺激和经皮神经电磁刺激等特殊的物理因子治疗；作业治疗中的运动想象、镜像治疗和疼痛暴露物理疗法等可以起到止痛和恢复肢体功能的作用。手术介入治疗包括交感神经阻滞、脊髓电刺激、射频和损毁术等，可用于保守治疗效果不佳时的顽固性疼痛。本文就国外近年来各学科的CRPS治疗方法进行总结，以期为临床医生进行CRPS的疼痛管理提供依据。

关键词: 复杂性区域疼痛综合征, 疼痛管理, 药物治疗, 康复治疗, 手术治疗

中图分类号:

R493

张雪晶, 曲福玲, 段晓琴, 刘颜芬, 刘忠良. 复杂性区域疼痛综合征治疗的研究进展[J]. 吉林大学学报(医学版), 2018, 44(05): 1090-1095.

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