参与生长板软骨生长和发育信号通路的研究进展

doi:10.13481/j.1671-587x.20190441

摘要/Abstract

摘要： 生长板是一种动态的高度分化的软骨结构，在软骨内骨化和骨的形成中发挥着极其重要的作用。目前已发现多种信号通路参与调控生长板软骨的生长和发育，如转化生长因子β（TGF-β）/骨形态发生蛋白（BMP）信号通路、WNT/β连环蛋白（β-catenin）信号通路、成纤维细胞生长因子（FGF）信号通路、刺猬因子（HH）信号通路、Notch信号通路、甲状旁腺激素相关蛋白信号通路、视黄酸信号通路、雷帕霉素靶蛋白（mTOR）信号通路和胰岛素样生长因子（IGF）信号通路等。现结合近几年国内外最新研究进展，回顾生长板软骨生长发育中涉及的关键信号通路以及信号通路转导过程中涉及的信号分子，阐述信号通路转导异常导致相关的软骨疾病发生的分子机制，旨在为临床生长板软骨遗传性疾病的诊断和治疗提供理论依据。

关键词: 生长板软骨, 生长, 发育, 信号通路

中图分类号:

R336

闫广兴, 刘苍维, 周怡君, 王爽爽, 胡月, 郝新青, 李道伟, 史册, 孙宏晨. 参与生长板软骨生长和发育信号通路的研究进展[J]. 吉林大学学报(医学版), 2019, 45(04): 971-975.

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