血栓弹力图、平均血小板体积/血小板计数比值和纤维蛋白原水平对复发性流产的预测价值

doi:10.13481/j.1671-587x.20200122

吉林大学学报(医学版) ›› 2020, Vol. 46 ›› Issue (01): 127-131.doi: 10.13481/j.1671-587x.20200122

血栓弹力图、平均血小板体积/血小板计数比值和纤维蛋白原水平对复发性流产的预测价值

于鹏跃, 赵凤莲, 张晓华, 赵丽娟, 赵丽艳

吉林大学第二医院检验科, 吉林长春 130041

收稿日期:2019-03-02 出版日期:2020-01-28 发布日期:2020-02-03
通讯作者: 赵丽艳,主任医师,硕士研究生导师(Tel:0431-81136607,E-mail:zhaoliy@jlu.edu.cn) E-mail:zhaoliy@jlu.edu.cn
作者简介:于鹏跃(1987-),女,吉林省长春市人,主治医师,医学硕士,主要从事止血和血栓方面的研究。
基金资助:
吉林省科技厅科技发展计划项目资助课题（20190201033JC）

Predictive values of thromboelastography, mean platelet volume/platelet count ratio and fibrinogen level in recurrent spontaneous abortion

YU Pengyue, ZHAO Fenglian, ZHANG Xiaohua, ZHAO Lijuan, ZHAO Liyan

Department of Clinical Laboratory, Second Hospital, Jilin University, Changchun 130041, China

Received:2019-03-02 Online:2020-01-28 Published:2020-02-03

摘要/Abstract

摘要： 目的：检测复发性流产（RSA）患者非孕状态下血栓弹力图（TEG）参数、平均血小板体积（MPV）/血小板计数（PC）比值和血浆纤维蛋白原（FIB）水平，并探讨其对该病的预测价值。方法：选择非孕状态下有RSA病史的患者206例为观察组，选取同期进行孕前检查的健康妇女92人作为对照组，检测受试者TEG各参数、MPV、PC和FIB水平，评估相关检测指标对RSA的预测价值。结果：与对照组比较，观察组受试者TEG参数中凝固时间（K值）降低（P<0.05），凝固角（α角）及最大振幅（MA值）升高（P<0.05），MPV/PC比值和FIB水平升高（P<0.05），2组受试者TEG参数中反应时间（R值）比较差异无统计学意义（P>0.05）。MA值、MPV/PC比值和FIB水平的受试者工作特征（ROC）曲线下面积（AUC）分别为0.694、0.673和0.735，表明三者对于RSA均有良好的临床预测价值。结论：RSA患者TEG中的K值、α角、MA值和MPV/PC比值及FIB水平在非孕状态时已有改变，其对RSA的早期预测价值较大。

关键词: 复发性流产, 血栓弹力图, 平均血小板体积, 血小板计数, 纤维蛋白原

Abstract: Objective: To detect the thromboelastrography (TEG) parameters, mean platelet volume(MPV)/platelet count(PC) ratio and plasma fibrinogen(FIB) level in the patients with recurrent spontaneous abortionin(RSA) in non-pregnant state, and to evaluate their predictive values in the disease. Methods: A total of 206 patients with RSA history were selected as observation group and 92 healthy women who underwent prenatal examination during the same period were selected as control group. The TEG parameters, MPV, PC and FIB levels of the subjects in two groups were measured, and the predictive values of relevant indicators in RSA were evaluated. Results: Compared with control group, the setting time (K value) of TEG parameters of the patients in observation group was decreased (P<0.05), the setting angle(α angle) and maximum amplitide(MA value) were increased (P<0.05), and the MPV/PC ratio and FIB level were increased (P<0.05). There was no significant difference in the response time(R value) of TEG parameters of the subjects between two groups (P>0.05).The areas under receiver operating characteristic (AUC) curve of MA value, MPV/PC ratio and FIB level were 0.694, 0.673 and 0.735,respectively. The results showed that the three paramerters had good clinical predictive values in RSA. Conclusion: The K value, α angle, MA value, MPV/PC ratio and FIB level in the RSA patients have changed in the non-pregnant state, which is of great value in the early prediction of RSA.

Key words: recurrent spontaneous abortion, thromboelastography, mean platelet volume, platelet count, fibrinogen

中图分类号:

R714.12

于鹏跃, 赵凤莲, 张晓华, 赵丽娟, 赵丽艳. 血栓弹力图、平均血小板体积/血小板计数比值和纤维蛋白原水平对复发性流产的预测价值[J]. 吉林大学学报(医学版), 2020, 46(01): 127-131.

YU Pengyue, ZHAO Fenglian, ZHANG Xiaohua, ZHAO Lijuan, ZHAO Liyan. Predictive values of thromboelastography, mean platelet volume/platelet count ratio and fibrinogen level in recurrent spontaneous abortion[J]. Journal of Jilin University(Medicine Edition), 2020, 46(01): 127-131.

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血栓弹力图、平均血小板体积/血小板计数比值和纤维蛋白原水平对复发性流产的预测价值

Predictive values of thromboelastography, mean platelet volume/platelet count ratio and fibrinogen level in recurrent spontaneous abortion

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