含缬酪肽蛋白促进单链RNA和双链DNA病毒复制或释放机制的研究进展

doi:10.13481/j.1671-587x.20200534

摘要/Abstract

摘要： 含缬酪肽蛋白（VCP）作为一种具有广泛功能的ATPase，在哺乳动物细胞内质网相关降解和泛素-蛋白酶体途径中发挥重要功能。VCP不仅参与真核细胞核酸的重建、膜损伤和细胞周期调控等生命活动，还在病毒对宿主细胞的感染、复制和释放过程中发挥调控作用。VCP能够促进西尼罗河病毒（WNV）、丙型肝炎病毒（HCV）、脊髓灰质炎病毒（PV）、肠道病毒71型（EV71）、冠状病毒（CoV）、基孔肯雅病毒（CHIKV）、辛德毕斯病毒（SINV）和裂谷热病毒等单链RNA病毒的复制或释放，还能促进加州苜蓿多核核型多角体病毒（AcMNPV）和人类巨细胞病毒（HCMV）等双链DNA病毒的复制。VCP通过其ATPase酶活性及参与的内质网相关降解（ERAD）和泛素-蛋白酶体等途径促进单链RNA和双链DNA病毒的复制或释放。现从VCP促进多种单股正链RNA、双链DNA病毒的复制和病毒粒子释放等3个方面综述近年来VCP同病毒感染相关的研究进展，为抗病毒治疗提供新的思路。

关键词: 含缬酪肽蛋白, 单链RNA病毒, 双链DNA病毒, 转录复制, 生活周期

中图分类号:

R373

徐娜, 桓晨, 郑柏松. 含缬酪肽蛋白促进单链RNA和双链DNA病毒复制或释放机制的研究进展[J]. 吉林大学学报(医学版), 2020, 46(05): 1099-1104.

XU Na, HENG Chen, ZHENG Baisong. Research progress in mechanism of valosin-containing protein in promoting replication or release of single-stranded RNA and double-stranded DNA viruses[J]. Journal of Jilin University(Medicine Edition), 2020, 46(05): 1099-1104.

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