TGF-β通路在椎间盘退变分子生物学进程中作用机制的研究进展

doi:10.13481/j.1671-587x.20200535

摘要/Abstract

摘要： 椎间盘退变的发生与椎间盘细胞流失、细胞外基质合成与降解失衡和局部炎症反应有密切关联。转化生长因子β（TGF-β）家族在椎间盘退变的分子生物学进程中发挥关键的调控作用，且在椎间盘的形成和发育过程中均发挥重要作用。另外，在退变的椎间盘中，TGF-β呈低水平表达，造成椎间盘组织细胞外基质表达水平降低、椎间盘细胞凋亡加速和椎间盘组织内炎症反应加强等不良反应，进一步加速了椎间盘组织的退变。同时，以TGF-β异常表达为靶点的分子生物治疗策略成为椎间盘退变治疗的新手段。适当激活TGF-β通路可以抑制细胞外基质降解、促进椎间盘细胞增殖并抑制其凋亡，并可以有效抑制椎间盘组织内炎症，起到延缓椎间盘退变发展、恢复椎间盘形态和高度及增加椎间盘组织负重的作用功能。但过度激活TGF-β通路反而会引起髓核细胞老化，加剧椎间盘退变。现回顾TGF-β通路在椎间盘发育和退变过程中的表达情况，并对TGF-β异常表达造成椎间盘退变中的分子生物学机制进行阐述。

关键词: 转化生长因子, 椎间盘退变, 细胞外基质, 髓核细胞, 纤维环, 炎症

中图分类号:

R681.53

王乙. TGF-β通路在椎间盘退变分子生物学进程中作用机制的研究进展[J]. 吉林大学学报(医学版), 2020, 46(05): 1105-1110.

WANG Yi. Research progress in mechanism of TGF-β signaling pathway in molecular biology process of intervertebral disc degeneration[J]. Journal of Jilin University(Medicine Edition), 2020, 46(05): 1105-1110.

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