吉林大学学报(医学版) ›› 2013, Vol. 39 ›› Issue (2): 383-387.doi: 10.7694/jldxyxb20130234

• 基础研究 • 上一篇    下一篇

宫腔镜结合B超手术治疗持续胎盘植入的疗效及安全性评价

赵艳忠1,赖爱鸾1,钱 敏1,张为远2   

  1. 1.首都医科大学附属复兴医院妇产科,北京100038;2.首都医科大学附属北京妇产医院
    妇产科,北京100023
  • 收稿日期:2012-07-28 出版日期:2013-03-28 发布日期:2013-03-26
  • 通讯作者: 张为远(Tel:010-85968396,E-mail:zhangwy9921@hotmail.com); 赖爱鸾(Tel:010-88062257,E-mail:laiailuan@sohu.com) E-mail:zhangwy9921@hotmail.com;laiailuan@sohu.com
  • 作者简介:赵艳忠(1968-),女,黑龙江省哈尔滨市人,副主任医师,副教授,在读 医学博士,主要从事妇科疾病基础与临床方面的研究。
  • 基金资助:

    国家自然科学基金资助课题(30770533)

Evaluation on effectiveness and safety of hysteroscopic 
resection combined with B ultrasound in treatment 
of retained placenta accreta

ZHAO Yan-zhong1,LAI Ai-luan1,QIAN Min1,ZHANG Wei-juan2   

  1. 1.Department of Obstetrics and  Gynecology,Fuxing Hospital,Capital  Medical University, Beijing 100038,China;2.Department of Obstetrics and Gynecology,Beijing Obstetrics and Gynecology Hospital,Capital  Medical  University,Beijing 100023,China
  • Received:2012-07-28 Online:2013-03-28 Published:2013-03-26

摘要: 目的:比较宫腔镜手术与药物保守治疗方法在持续胎盘植入治疗中应用的效果,阐明宫腔镜技术诊断及治疗持续胎盘植入的有效性和安全性。方法:选择
47例持续胎盘植入临床病例资料进行回顾性分析,其中粘连型7例,植入型38例,穿透型2例。孕早期7例,孕中期19例,孕晚期21例。根据治疗方法不同将植入型胎盘38例分为宫腔镜下植入胎盘电切术组(n=20)及米非司酮+甲氨蝶呤药物治疗组(n=18),通过B超和人绒毛膜促性腺激素(HCG)转阴率以及3个月月经恢复正常率等比较2种治疗方法的疗效。结果:各孕期发生胎盘植入的危险因素基本一致,最常见的危险因素是刮宫,占65.9%(31/47);
其次为剖宫产,占34.0%(16/47)。孕早期以粘连型为主,占85.7%(6/7);孕中、晚期主要以植入型为主,占92.5%(37/40)。本组47例患者中采用宫腔镜治疗胎盘植入27例,包括粘连型7例,植入型20例;除外1例植入型同时行腹腔镜下子宫动脉结扎术,其余均在B超监测下完成;20例植入型中19例一次手术完成,1例经过2次手术。宫腔镜下植入胎盘电切术组中20例植入型患者B超转阴率及3个月月经恢复正常率均为100%,未发现远期并发症; 药物治
疗中18例植入型患者B超转阴率64.7%,3个月月经恢复正常率58.8%,2组植入型患者比较差异有统计学意义(P<0.05);2组植入型患者HCG转阴率差异无统计学意义。结论:宫腔镜结合B超手术治疗持续胎盘植入较药物治疗更有效。

关键词: 持续性胎盘植入, 宫腔镜, B型超声, 人绒毛膜促性腺激素, 米非司酮, 甲氨蝶呤

Abstract: Objective To  evaluate the safety and effectiveness  of hysteroscope in diagnosis and treatment of retained placenta accreta by comparing the clinical effects of two methods of hysteroscope and medicine  in treatment of  placenta accreta.Methods A retrospective analysis  of fourty-seven patients with retained placenta accreta  including  7 cases of placenta accreta,38 cases of placenta increta,2 cases of  placenta percreta.There were 7 cases in first trimester,19 cases in second trimester,and 21 cases in last trimester.38 patients with placenta increta were treated with hysteroscopic resectin(n=20) and mifeprist
one+methotrexate(n=18),respectively.The clinical effects of two methods were compared by detecting the B ultrasound negative rate,negative rate of human chorionic gonadotropin(HCG) and 3-month normal menstruation rate.Results The risk factors of placenta accreta in various trimesters were basically c
onsistent. Among them curretage was the first risk factor of   placenta accrete,65.9%(31/47);the second was cesarean,34.0%(16/47).85.7%(6/7) placenta accrete was placenta accrete in first trimester; 92.5%(37/40) was placenta increta in second and third trimesters. 27 cases were cured by
hysteroscopic resection controlled by B ultrasound.A simultaneous laparoscopy was performed in 1 case.19 cases were completed in one operation,and 1 case underwent two operations.There was no complication.The B ultrasound negative rate and 3-month normal menstruation rate in hysteroscope group(100%,100%) were higher than those in medicine group(64.7%,58.8%)(P<0.05).There was no significant difference of negative rate of HCG between two groups(P>0.05).Conclusion The treatment of combined hysteroscope and B ultrasound is more effective than medicine.

Key words: retained placenta accreta, hysteroscope, B ultrasound, human chorionic gonadotropin, mifepristone, methotrexate

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