关键词: 血管紧张素Ⅱ, 拮抗剂和抑制剂, 血管内膜, 损伤, 增生

Abstract: Objective To study the effects of angiotensin converting enzyme inhibitor（captopril） and angiotensin Ⅱ antagonist receptor (valsartan) on neointima hyperplasia after vascular balloon injury. Methods Thirty-six rabbit models were randomly divided into three groups:injuried group，captopril group and valsartan group. Captopril (2 mg•kg^-1•d^-1 po) and valsartan (10 mg•kg^-1•d^-1 po) were given to twelve rabbits respectively from 1 day before the right carotid arteries were injuried by 2.0 mm ballon cathether to 14 days after injury in captopil group and valsartan group. The medicine was not administered in the injuried group. The tissue plasminogen activator (tPA),plaminogen activor inhibitor-1(PAI-1) antigen level and plasma endothelin (ET) levels were measured before injury, and 7,14 days after vascular injury. The pathomorphoiogical examination were carried out 14 days after angioplasty. Results The levels of plasma PAI-1 and ET in captopril group and valsartan group were significantly lower than those in the injuried group(P<0.05).The intimal thickness and extent of lumen stenosis in captopril and valsartan groups were significantly lower than those in the injuried group (P<0.05). Conclusion Captopril and valsartan can inhibit neointima hyperplasia after vascular ballon injury.

Key words: angiotensin Ⅱ, antagonists and inhibitors, vessel intimal, injury, hyperplasi