关键词: C反应蛋白, 胰腺炎, 血液

Abstract: Objective To evaluate the relationship between serum IL-10 and c-reactive protein (CRP) in patients with acute pancreatitis (AP) and the severity of AP and its clinical significance. Methods The levels of serum IL-10 and CRP were determined by ELISA in 12 healthy subjects and 45 patients with AP on the 1st,2nd,3rd,4th and 5th days after onset. Results The serum IL-10 was not found in control group. The levels of serum IL-10 was increased on the 1st day of onset, then was decreased. The level of IL-10 in patients with mild acute pancreatitis (MAP) was significantly higher than that in patients with severe acute pancreatitis (SAP) on the 1st day of onset; the levels of serum IL-10 was hgihest in patients with MAP on the 1st day of onset;it was higher in patients with SAP on the 1st,2nd and 3rd days than that on the 4th and 5th days (P<0.05).Conclusion The change of serum IL-10 in patients with AP may be used as early accessory diagnosis of AP. The level of serum IL-10 on the 1st day of onset may be used to identify MAP and SAP. The combinated determine of IL-10 and CRP may be used as one index to judge the prognosis.

Key words: C-reactive protein, pancreatitis, blood