关键词: 外科学, 疾病模型, 动物

Abstract: Objective To investigate the long-term effects of portal vein hemodynamic changes on liver function after portal vein arterialization(PVA) in rats. Methods The rats were divided into PVA group and control group. The common liver artery was anastomosed with the proximal portal vein by end-side way, and the distal portal vein with the vena cava by side-side way in PVA group for the sake of establishing the models of rat PVA. The abdominal cavity was closed after dissociating the liver hilar tissue in control group.The blood flow volume and cross section in two groups operated for one month and six months ,respectively, were observed. The portal vein pressure, liver function and structure after six months were observed. Results Compared with control group, the cross section and blood flow volume of portal vein had a increasing trend in PVA group（P<0.05）.Portal vein pressure,the levels of plasma endotoxin,serum albumin,bile acid salt,DBIL and TBIL didn′t present distinct difference（P>0.05）. But the level of serum GPT in PVA group increased evidently（P<0.05）,and the walls thickened and the proportion of collagen increased in distended portal vein and its branches. Conclusion The PVA without limiting the blood flow volume can increase the cross section and blood flow volume of portal vein ,dilate and thicken the branches of portal vein, but the function of reticuloendothelial system, metabolism of bile pigment and bile acid salt don′t undergo significant influences.

Key words: surgery, disease models, animal