关键词: 再灌注损伤 , 活性氧

Abstract: Objective To study the effects of Shengmai injection on alleviating myocardial ischemia and preventing the reperfusion injury when it was applied as the additive of the perfusion liquid in the process of cardiac surgery with cardiopulmonary bypass (CPB). Methods Sixty cardioetomy patients were randomly divided into experimental group (n=30) and control group (n=30). In the experimental group, the Shengmai injection was added to the reformative Thomas solution.The serum CK-MB and SOD levels were determined in experimental and control groups.The changes of myocardial ultrastuctures were observed under electron microscope. Results The level of CK-MB was significantly lower in the experimental group than that in the control group(P<0.05 ).The level of SOD in experimental group was significantly higher than that in the control group(P<0.05).The result of mitochondria morphological measurement indicated that the mitochondrial face number density and specific surface were significantly higher in the experimental group than those in the control group (P<0.05 or P<0.01). Conclusion Shengmai injection acted as the additive of the the cold stopping-pulse solution could protect the myocardial membrane and the ultrastructure of myocardium and debate the damage in the cardioetomy and eliminate the oxygen free radical.

Key words: reperfusion injury, reactive oxygen species