IL-6基因多态性与短暂性脑缺血发作的关系

doi:吉林省中医局资助课题（吉中医9810）；黑龙

IL-6基因多态性与短暂性脑缺血发作的关系

宋冬晶¹，陈加俊^1*，邬英全¹，赵庆杰²，汤赜³

1. 吉林大学中日联谊医院神经内科，吉林长春 130031; 2. 哈尔滨医科大学附属第一医院神经内科，黑龙江哈尔滨150001; 3. 吉林大学基础医学院免疫学教研室，吉林长春130021

收稿日期:2004-11-01 修回日期:1900-01-01 出版日期:2005-11-28 发布日期:2005-11-28
通讯作者: 陈加俊

Association between polymorphism of IL-6 gene and TIA

SONG Dong-jing¹,CHEN Jia-jun^1*,WU Ying-quan¹,ZHAO Qing-jie²,TANG Ze³

1.Department of Neurology,China-Japan Union Hospital,Jilin University,Changchun 130031,China;2. Department of Neurology,First Affilicated Hospital,Haerbin Medical University,Haerbin 150001,China;3. Department of Immunology,School of Basic Medical Sciences,Jilin University,Changchun 130021,China

Received:2004-11-01 Revised:1900-01-01 Online:2005-11-28 Published:2005-11-28
Contact: CHEN Jia-jun

摘要/Abstract

摘要： 目的:研究IL-6基因启动子区域 (-174)位点G/C碱基多态性与短暂性脑缺血发作（TIA）的发病率及其临床进程之间的关系。方法:临床确诊的121例TIA患者和114例同年龄段、同性别组成的健康对照者，采血并用MS-PCR法对基因型进行检测，随访3个月，记载3个月内进展为脑梗塞的情况。结果:TIA患者的GG型基因比例（54.6%）明显高于对照组（38.6%）(P<0.05)，也明显高于其他两型（GC 30.6%，CC 14.9%）(P<0.05)。GG型患者66例，3个月内发展为脑梗塞者28例（42.4%），与GC型(16.2%，6/37)、CC 型（16.7%，3/18）相比，差异有显著性（P<0.05)。结论:IL-6基因启动子区域GG型与TIA的发病及预后有明显的相关性。

关键词: 多态现象（遗传学）, 脑缺血发作, 短暂性

Abstract: Objective To investigate the statistical association between the G/C promoter polymorphism at (-174) of the IL-6 gene and transient ischemia attack(TIA) events, as well as the progress of cerebral infarction in 3 months.Methods 121 TIA patients and 114 age- and sex- matched healthy control subjects were examined for the (-174) IL-6 G/C polymorphism by mutagenic separated polymerase chain reaction (MS -PCR).The progress of cerebral infarction in 3 months was recorded. Results In the patients with TIA,the pro-portion of genotype GG（54.6%）was significantly higher than that in the control group（38.6%）(P<0.05)，and also higher than those of GC(30.6%) and CC (14.9%）(P<0.05).The incidence rate of cerebral infarction in 3 months had significant differences between GG patients（28/66,54.6%） and GC（6/37，16.2%），CC（3/18， 16.7%）(P<0.05).Conclusion The genotype GG of IL-6 promoter is associated with pathogenesis and prognosis of TIA.

Key words: polymorphism(genetics), ischemic attack, transient

中图分类号:

R743.31

宋冬晶，陈加俊，邬英全，赵庆杰，汤赜. IL-6基因多态性与短暂性脑缺血发作的关系[J]. J4, 2005, 31(6): 924-926.

SONG Dong-jing,CHEN Jia-jun,WU Ying-quan,ZHAO Qing-jie,TANG Ze. Association between polymorphism of IL-6 gene and TIA[J]. J4, 2005, 31(6): 924-926.

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