关键词: 海人酸, 杏仁核, 脑电图, 海马, 顶叶

Abstract: Objective To record the electroenciphalogram(EEG) in hippocampus or parietal cortex and then compare them in epileptic rats kindled by kainic acid(KA) microinjection into nucleus amygdalae. Methods KA was microinjected(1 μg) into right nucleus amygdalae of male Wistar rats with stereotaxic technique to establish kindling epileptic model. Observation of praxiology was carried while recordin g of the EEG in hippocampus and parietal cortex were performed successively for 6 h after KA injection. Results Many kinds of epileptic discharges presented in the kin dled rats, especially the multiple spike waves were common. There were no significant differences in the latency to onset, period of discharge(PD) per hour, total PD in 6 h and the amplitude of wave between EEG of hippocampus and that of parietal cortex. Conclusion The changes of EEG in rats kindled by KA microinjection into nucleus amygdalae are consistent with that of temporal lobe epilepsy. Seizures are quickly spread inter-cortex. The epileptic discharges of hippoc ampus opposite to kindling focus are highly coincident to that of parietal cort ex. Motoring the EEG of parietal cortex may refer to observe the changes in electrophysiology for this model.

Key words: kainic acid, amygdala, electroenciphalogram, hippocampus, parietal loke