关键词: 遗传学, 多态性, 单核苷酸, PLA2G4A, 基 因型

Abstract: Objective To investigate the genetic association between polymorphism of PLA2G4A gene in chromosome 1 and schizophrenia in the Han people of Northern China. Methods The method of PCR-RFLP was conducted to examine the genotypes of PLA2G4A gene in samples of 235 Chinese Han family trios consisting of fathers, mothers and affected offsprings with schizophrenia. Then the analysis of haplotype relative risk (HRR) and transmission disequilibrium test (TDT) were used to deal with the data statistically. Results The genotypic frequency of PLA2G4A gene did not deviate from Hardy-Weinberg equilibrium in both case and control groups（P>0.05）; HRR analysis did not show a significant difference in the allelic (A and G) frequency of PLA2G4A gene between transmit and untransmit (P＞0.05); TDT analysis suggested that the possibility of the two different alleles transmitted from the heterozygotic parents didn′t deviate from 50%（P＞0.05). Conclusion The PLA2G4A gene in chromosome 1 may be not the susceptible gene of schizophrenia.

Key words: genetics, polymorphism, single nucleotide, PLA2G4A, genotype