关键词: 血小板膜糖蛋白类, von Willebrand, 急性病, 综合征

Abstract: Objective To study the effects of Ozagre on CD62p,CD61, which was used as platelet marks and von willebran factor (vWF) in patients with acute coronary syndrome (ACS),and meanwhile to study the relationships between CD62p,CD61 and vWF. Methods CD62p ,CD61 from whole-blood samples were measured by FCM and vWF was measured by ELISA method in 36 patients with ACS and 20 normal peoples used as control group. Results The amount of expression of CD62p was（89.60±6.98）% in ACS patients group and （40.88±7.56）% in control group, there was obvious difference between ACS group and control group (P<0.05). The amount of CD62p was decreased to (66.11±8.72)% after treated with Ozagre (P<0.05). There was also significant difference of CD62p in ACS group between before and after intervention of ozagre (P<0.05). The amount change of CD62p in patients with ACS was agreement with the improvement of angina pectoris and the changes in sum of ST segements. However there was no difference of CD61 between ACS group and control group (P>0.05).There was also no difference of CD61 between before and after treatment of Ozagre(P>0.05). Conclusion CD62p is a sensitive index of platelet activation in ACS patients and there is excellent relationship between CD62p and vWF and clinical symptoms.

Key words: platelet membrane glycoproteins, von Willebran factor, acute disease, syndrome