关键词: 糖尿病, 四氧嘧啶, 肾上腺素, 自由基, 胰岛素

Abstract: To study the hypoglycemic activity of Injection of Ginseng Fruit Saponins (IGFS).Methods Fasting blood glucose (FBG),the contents of hepatic glycogen and the serum malondialdehyde (MDA) and activity of the serum super oxide dismutase (SOD) were determined in hyperglycemia rats induced by alloxan 14 d after administration of IGFS (in dosages of 7.5-30.0 mg•kg^-1 intraperitoneal injection).FBG and the content of hepatic glycogen were determined in hyperglycemia mice induced by adrenaline 7 d after administration of IGFS (in dosages of 10-40mg•kg^-1 intraperitoneal injection).At the same time,FBG and contents of the serum insulin and C-peptide were also observed,and insulin sensitive index (ISI) was calculated in normal rats pretreated with IGFS (in dosages of 7.5－30.0 mg•kg^-1 intraperitoneal injection). Results In hyperglycemia rats induced by 1.5% alloxan with sublingual vein injection,compared with normal group,FBG and content of the serum MDA in model group were increased significantly（P<0.05）,while the content of hepatic glycogen and activity of the serum SOD were decreased（P<0.05）; however,compared model group,FBG and content of the serum MDA were decreased significantly（P<0.01）,the content of hepatic glycogen and activity of the serum SOD were increased（P<0.05）by IGFS (in dosages of 7.5,15.0, and 30.0 mg•kg^-1 intraperitoneal injection for 14 d) in hyperglycemia mice induced by 0.1% adrenaline with subcutaneous injection.Compared with model group,FBG was reduced（P<0.01） and the content of hepatic glycogen was increased（P<0.05）by IGFS (in dosages of 20.0 and 　40.0 mg•kg^-1 intraperitoneal injection for 7 d).The content of the serum C-peptide was increased significantly（P<0.05 or P<0.01）while FBG and the content of serum insulin and ISI changed little in normal rats pretreated with IGFS (in dosages of 15.0 and 30.0 mg•kg^-1 intraperitoneal injection for 7 d). Conclusion IGFS possesses the hypoglycemic action on experimental hyperglycemia models induced by alloxan and adrenaline,which be related to scavenging the oxygen free radicals,restraining lipid peroxidation and increasing transformation and utilization of glucose.

Key words: diabetes mellitus, alloxan, adrenaline, free redicals, insulin