关键词: 高脂血症, 模型, 动物

Abstract: To observe the action of lowering blood fat of corn filament beverage (CFB) on hyperlipemia rats and mice.MethodsSixty rats were randomly divided into control group,alloxan model group,kanglishu capsule 0.70 g•kg^-1 group,CFB 7.00,3.50,1.75 mL•kg^-1 groups(n=10). Rats in each group were exhibited once a day for 21 d,on the seventh day,fourteenth day,twenty-first day, the contents of serum total cholesterol (TCHO) and triglyceride(TG) were determined,and liver malonaldehyde (MDA) level was measured. Another 60 mice were divided into 6 groups with the method mentioned above,mice in each group were exhibited once a day for 14 d,on the fourteenth day,the serum contents of TCHO and TG were determined,and liver MDA level was determined.Another 72 mice were randomly divided into control group,egg yolk model group,Expellant and Cleanning Fat Capsule 0.4 g•kg^-1 group,CFB 10.0,5.0,2.5 mL•kg^-1 groups (n=12).Mice in each group were exhibited once a day for 10 d.16 h before the last administration,except control group,the mice in other groups were injected with 75% yolk physiological salt solution 0.5mL through the abdominal cavity,and began to starve,1 h after the last administration, the contents of serum TCHO and TG were determined,and liver MDA level was measured. Results Compared with alloxan model group,TCHO and TG in hyperlipemia rats of CFB 7.00 mL•kg^-1 all reduced obviously　(P<0.001),the MDA content of each dose all reduced obviously(P<0.001,P<0.001,P<0.01),and showed a certain relation between quantity and effect. Compared with alloxan model mice,TCHO and TG in hyperlipemia mice of CFB 10.0 mL•kg^-1 all reduced obviously（P<0.01）,the MDA content of each dose all reduced obviously（P<0.001,P<0.001,P<0.01）,and showed a certain relation between quantity and effect. Compared with egg yolk model mice,TCHO in hyperlipemia mice of CFB 10.0 mL•kg^-1 all reduced obviously（P<0.01）,TCHO in hyperlipemia mice of CFB 10.0,5.0 mL•kg^-1 all reduced obviously（P<0.01,P<0.05）, the MDA contents of CFB 10.0,5.0 mL•kg^-1 reduced obviously （P<0.001,P<0.01 ）. CFB 7.0 mL•kg^-1was superior to Kanglishu Capsule in reducin g TCHO,TG and MDA,CFB 10.0 mL•kg^-1 was superior to Expellant and Cleanning Fat Capsule. ConclusionCFB has the function of lowering blood fat on hyperlipemia rats and mice.

Key words: hyperlipidemia, models, animal