关键词: 生殖毒性, 乳酸脱氢酶, 6-磷酸葡萄糖脱氢酶

Abstract: To observe the effects of bisphenol A (BPA) on the reproductive function in F1 mice. Methods Pregnancy mice were divided into four groups randomly. From the beginning of pregnance,the mice in experimental groups were given BPA with 30,120,360 mg•kg^-1•d^-1 until the new mice were born. The mice in control group were given the same volume of corn oil. When the young mice were 30 d, the sperm malformation rate,the activities of lactic acid dehydrogenase(LDH) and glucose-6-phosphate dehydrogenase(G-6-PD) of testicle,the organ coefficient, the histopatholgical changes of testicle in male mice were examined. Results The form of the epithelial cells of seminiferous tubules was disordered. The number of mature spermatozoa was decreased. This changes were more and more with the increase of BPA dose. Compared with control group,organ coefficients in low and large dose groups reduced,LDH activity and G-6-PD activity in middle and large dose groups decreased,LDH activity in low dose group increased. The sperm malformation rates in experimental groups increased as the increase of BPA dose, the differences were remarkable(P<0.01). Conclusion BPA given in embryonic period can influence the reproductive function of F1 mice.

Key words: reproductive toxicity, lactic acid dehydrogenase, glucose-6-phosphate dehydrogenase