关键词: RhoC蛋白, 明胶酶A, 免疫组织化学

Abstract: To study the expressions of RhoC and MMP-2 proteins in epithelial ovarian cancer and their clinical significances in order to provid the basis for assessing the biological behaviour of epithelial ovarian cancer.Methods Immunohistochemistry was used to detect the expressions of RhoC and MMP-2 proteins in 10 cases of normal ovarian tissues,12 cases of epithelial benign ovarian tumor and 91 cases of epithelial ovarian cancer,and the relationship with the clinical features was analyzed.Results The RhoC and MMP-2 proteins positive expression rates in ovarian benign tumor and ovarian normal tissues were 0 respectively; the positive expression rates of RhoC and MMP-2 proteins in epithelial ovarian cancer were 37.3% and 68.1%.The expressions of RhoC and MMP-2 proteins in ovarian cancer were significantly higher than those in ovarian benign tumor and ovarian normal tissues.The positive expression rates of RhoC and MMP-2 in moderately and poorly differentiated cancer were significantly higher than those in well differentiated cancer(P<0.005).The positive expression rates of RhoC and MMP-2 in Ⅲ-Ⅳclinical stage cancer were significantly higher than those inⅠ-Ⅱstage cancer(P<0.005 ).The expressions of RhoC and MMP-2 proteins in ovarian cancer with metastasis were significantly higher than those in ovarian cancer without metastasis(P<0.005,P<0.05).The expression of RhoC had positive correlation with the expression of MMP-2 in ovarian cancer(r=0.492,P<0.05).Conclusion The expressions of RhoC and MMP-2 proteins show positive correlation with the cell differentiation,clinical stage and metastasis of ovarian cancer.The clinical detection of RhoC and MMP-2 protein expressions in ovarian cancer can be used as a indicator to judge the biological behavior and prognosis of ovarian cancer.

Key words: RhoC protein, gelatinase A, immunohistochemistry