氟比洛芬酯超前镇痛效果及其对开胸患者术后肺功能影响的评价

J4 ›› 2009, Vol. 35 ›› Issue (3): 515-518.

氟比洛芬酯超前镇痛效果及其对开胸患者术后肺功能影响的评价

李艳辉¹, 韩灵¹, 王丹², 麻海春¹

1.吉林大学第一医院麻醉科|吉林长春 130021；2.吉林省前卫医院麻醉科|吉林长春 130012

收稿日期:2008-07-18 出版日期:2009-05-28 发布日期:2009-08-14
通讯作者: 麻海春 E-mail:mahaichun2003@yahoo.com.cn
基金资助:
吉林省科技厅科研基金资助课题（0505226）

Preemptive analgesia effects of flurbiprofen axetil on respiratory function in patients undergoing thoracotomy

LI Yan-Hui¹, HAN Ling¹, WANG Dan², MA Hai-Chun¹

1.Department of Anesthesiology,First Hospital, Jilin University,Changchun 130021|China；2.Department of Anesthesiology|Qianwei Hospital of Jilin Province,Changchun 130012|China

Received:2008-07-18 Online:2009-05-28 Published:2009-08-14

摘要/Abstract

摘要：

目的：研究氟比洛芬酯的超前镇痛效果及对开胸患者术后肺功能的影响。方法：20例ASA1～2级开胸手术患者随机分为氟比洛芬酯组（实验组，n=10）和对照组（n=10），于切皮前15 min，实验组静脉滴注氟比洛芬酯5 mL（50 mg），对照组静脉滴注生理盐水5 mL，观察两组术后4、8、12、24和48 h视觉模拟评分(VAS)及不良反应发生率，记录PCA泵按压次数，计算单位时间舒芬太尼用量。测量术前及术后24和48 h肺功能（FVC、FEV1、MMEF）。结果：术后4、8、12、24和48 h实验组 VAS均低于对照组（P<0.05），术后单位时间舒芬太尼用量实验组明显低于对照组（P<0.05）。术后PCA泵手动按压及有效按压次数实验组均少于对照组（P<0.05）。术后4、8、12、24和48 h两组肺功能参数均低于术前值，术后24和48 h肺功能值对照组均低于实验组，但差异无显著性（P>0.05）。术后两组恶心、呕吐等不良反应发生率差异无显著性（P>0.05）。结论：氟比洛芬酯应用于开胸患者具有超前镇痛的作用，且术前单次应用不增加胃肠道并发症的发生率；从肺功能改善情况看，其超前镇痛效果不足以产生临床意义。

关键词: 超前镇痛；氟比洛芬酯；肺功能；患者自控静脉镇痛；开胸手术

Abstract:

To study the preemptive analgesia effects of flurbiprofen axetil on respiratory function in patients undergoing thoracotomy.Methods Twenty male patients undergoing thoracotomy were devided into two groups equally with ten cases each to receive either flurbiprofen axetil 5 mL (50 mg) (experiment group) or saline 5mL(control group) 15 min before incision.At the end of the surgery both groups received intravenous sufentanyl PCA with a loading dose of 10 g,a maintenance dose of 2 g•h<^1,a bolus dose of 2 g and a lockout interval of 15 min.Age,weight,sex,history of general anaesthesia were recorded.Analgesia grades at 4，8，12，24，and 48 h after operation were accessed and side effects(nausea and vomiting) were recorded.Total drug use,number of boluses delivered,number of boluses demanded were collected.Pulmonary function (FVC,FEV1,MMEF) was tested the day before operation,as well as at 24 and 48 h after operation.Results No differences between two groups were found for demographic data.There were also no clinically relevant differences between two groups with regard to side effects (P>0.05).Significant differences were observed in analgesia grade between two groups.Visual analogue scores (VAS) in different postoperative time points (4,8,12,24 and 48h) were lower in experiment group than those in control group (P<0.05).Also less bolus doses were demanded and delivered in experiment group (P<0.05).Respiratory function test in both groups was not as good as that before operation. 24 and 48 h after operation,the respiratory function test was better in experiment group than that in control group, but there was no significant difference(P>0.05).Conclusion Flurbiprofen axeti1 has preemptive analgesia effects with the chosen dosage regimen in patients undergoing thoracotomy and doesn’t increase side effects.But the preemptive analgesia can’t improve postoperative respiratory function.

Key words: preemptive analgesia;flurbiprofen axetil, respiratory function;patient control intravenous anagesia;thoracotomy

中图分类号:

R614

李艳辉, 韩灵, 王丹, 麻海春. 氟比洛芬酯超前镇痛效果及其对开胸患者术后肺功能影响的评价[J]. J4, 2009, 35(3): 515-518.

LI Yan-Hui, HAN Ling, WANG Dan, MA Hai-Chun. Preemptive analgesia effects of flurbiprofen axetil on respiratory function in patients undergoing thoracotomy[J]. J4, 2009, 35(3): 515-518.