关键词: 奥扎格雷钠；心肌缺血；丙二醛；超氧化物歧化酶；大鼠  

Abstract:

Objective
To disccuss the antioxidative effects of sodium ozagrel (OZG) in myocardial ischemia in rats and illuminate its effect of decreasing oxidative damage.Methods Forty healthy Wistar rats were randomly devided into five groups:control,model,pretreatment,treatment and therapeutic alliance groups.OZG was used for 2 weeks in pretreatment group,then isoprenaline hydrochloride (ISO) was applied to make myocardial ischemia model.5 min after the establishment of model,OZG and OZG combined with glyceryl trinitrate(GT) were used in treatment group and therapeutic alliance group,respectively,ECG was recorded at the same time.1 h later,the activities of serum myocardial creatases (AST,LDH,CK),malonaldehyde(MDA) level and superoxide dismutase(SOD) activity were detected.Results ECG:When the model was successfully set up,ST segment in every group all raised≥0.1 mV,the minimum value of raise was in pretreatment group.When the model was succeeded 5 min later,ST segment in model group slightly decreased but still ≥0.1 mV and it was significant in pretreatment group. In treatment and therapeutic alliance groups,compared with model succeeding’ST segment,ST segment decreased significantly at 5 min later(P<0.05),the best obvious in therapeutic alliance group.Myocardial creatases:compared with control group,AST,LDH and CK all raised in model group respectively and all had significant difference (P<0.05).In pretreatment,treatment and therapeutic alliance groups,myocardial creatases were lower than those in model group (P<0.05).Compared with control group,when model succeeding,MDA raised (P<0.05) and SOD decreased in model group(P<0.05).It also appeared in pretreatment and therapeutic alliance groups compared with model group(P<0.05).Compared with treatment group,SOD raised in pretreatment and therapeutic alliance groups(P<0.05).Conclusion OZG could enhance antioxygen capability in myocardial cells,and decrease oxidative damage by the active free radical.

Key words: ozagrel;myocardial ischemia;malonaldehyde;superoxide dismutase