J4 ›› 2009, Vol. 35 ›› Issue (6): 1147-1150.

• 基础研究 • 上一篇    下一篇

芪苈强心胶囊治疗慢性充血性心力衰竭效果评价

丁梅,杨萍,何敏,冯朝晖   

  1. 吉林大学中日联谊医院心内科|吉林 长春 |130033
  • 收稿日期:2009-06-02 出版日期:2009-11-28 发布日期:2009-11-28
  • 通讯作者: 杨 萍 E-mail:mding821017@yahoo.com.cn
  • 作者简介:丁 梅(1982-)|女|河北省沙河市人|医师|医学硕士|主要从事心血管疾病诊治研究。
  • 基金资助:

    国家自然科学基金资助课题(30770883);长春市科技局社发处计划项目资助课题 (06GG28)

Evaluation of curative effects of Qiliqiangxin capsule in treatment of patients with chronic congestive heart failure

 DING Mei, YANG Ping, HE Min, FENG Chao-Hui   

  1. Department of Cardiology|China-Japan Union Hospital|Jilin University|Changchun 130033|China
  • Received:2009-06-02 Online:2009-11-28 Published:2009-11-28

摘要:

目的:观察芪苈强心胶囊治疗慢性充血性心力衰竭(CHF)的临床疗效。方法:将64例CHF患者采用随机数字表随机分为治疗组33例和对照组31例,两组基线水平无差异,两组均应用洋地黄、利尿剂、ACEI等常规治疗,治疗组加服芪苈强心胶囊。比较两组患者治疗前后出汗改善情况、心功能好转率、6分钟步行距离、血清离子变化及用药期间的不良反应。结果:治疗1、2周后治疗组患者出汗缓解率高于对照组(P<0.05)。治疗1周后两组患者心功能和6分钟步行距离均较治疗前提高,但组间比较差异无显著性(P>0.05),2周后治疗组优于对照组(P<0.05)。治疗1周后两组患者血清Na+水平均较治疗前降低,但组间比较差异无显著性(P>0.05);2周后治疗组血清Na+水平高于对照组(P<0.05)。治疗1、2周后两组血清K+水平比较差异无显著性(P>0.05)。治疗组和对照组患者未出现任何不良反应,无停用芪苈强心胶囊者。结论:芪苈强心胶囊对患者止汗作用明显,短期内即可见效;有一定的强心作用,但起效相对慢;有一定的保钠作用,对血钾影响不大;耐受性好。

关键词: 心力衰竭,充血性;芪苈强心胶囊;电解质紊乱;低钠血症

Abstract:

Objective
To study the clinical effect of Qiliqiangxin capsule (QC)  in patients with  chronic congestive heart failure (CHF). Methods According to random number table,64 CHF patients were randomly assigned into therapy group (n=33) and control group (n=31).During the treatment,sweat secretion,heart function improved rate,6 min walking distance,the side-effect and compliance were observed.The levels of serum Na+ and K+ of patients were measured on the 2nd,8th and 15th hospital day.Results  Compared with control group,the remission rate  of sweat secretion in therapy group was higher after treatment (P<0.05).One week later,heart function and 6 min walking distance were improved in both groups,but there was no significant difference between two groups(P>0.05);compared with control group,the improved rates of heart function and 6 min walking distance in therapy group were higher after two weeks (P<0.05).There was no significant difference between two groups of the level of serum Na+ on the 8th hospital day(P>0.05);on the 15th day,the level of serum Na+ in therapy group was higher than that in control group (P<0.05). There were no significant differences between two groups of the level of serum K+ on the 8th or 15th hospital day(P>0.05).During treatment,33 patients had not any uncomfortable complain about this drug and nobody stopped using this capsule;while there was no complain from the patients of control group.Conclusion  The effect of QC about releasing hyperidrosis in a short time is conspicuous.QC can improve heart function,but it plays this role gradually.QC can keep the level of serum Na+ to some extent.There is no influence on the level of serum K+.The tolerance of this capsule is well.

Key words: heart failure,congestive, Qiliqiangxin capsule;electrolyte disturbances;hyponatremia

中图分类号: 

  • R541.61