伐地那非联合心理疗法治疗老年男性肾移植受者勃起功能障碍的疗效评价

J4 ›› 2010, Vol. 36 ›› Issue (1): 192-194.

伐地那非联合心理疗法治疗老年男性肾移植受者勃起功能障碍的疗效评价

洪泉¹|周洪澜²|王伟刚²|傅耀文²

1. 解放军空军总医院泌尿外科|北京100142；2. 吉林大学第一医院泌尿系统疾病诊治中心|吉林长春130021

收稿日期:2009-09-15 出版日期:2010-01-28 发布日期:2010-01-28
通讯作者: 傅耀文（Tel:0431-88782905，E-mail:fuyaowen@medmail.com.cn） E-mail:fuyaowen@medmail.com.cn
作者简介:洪泉（1956-）|男|吉林省长春市人|主任医师|主要从事器官移植方面的基础及临床研究。
基金资助:
吉林省科技厅科技发展计划项目资助课题（200705136）

Evaluation of curative effect of vardenafil combined with mental intervention for erectile |dysfunction in aged male kidney transplant recipients

HONG Quan¹, ZHOU Hong-Lan², WANG Wei-Gang², FU Yao-Wen²

1.Department of Urinary Surgery,Air Force General Hospital of PLA,Beijing 100142,China;2.Center of Urology,First Hospital,Jilin University,Changchun |130021,China

Received:2009-09-15 Online:2010-01-28 Published:2010-01-28

摘要/Abstract

摘要：

目的：评估伐地那非联合心理疗法治疗老年男性肾移植受者勃起功能障碍（ED）的有效性及安全性。方法：随机选取50岁及以上、肾移植术后1年及以上和血肌酐150 μmol?L-1的肾移植受者120例，应用国际勃起功能指数（IIEF）进行肾移植术后性功能状况评分，存在ED者给予伐地那非联合心理治疗6个月，重新采用IIEF来评估其有效性。监测患者血清肌酐值、肌酐清除率、肝功能及免疫抑制剂（环孢素及普乐可复）浓度以评估伐地那非的安全性。结果：120例肾移植受者中78例存在ED。78例ED患者采用伐地那非联合心理治疗6个月后，IIEF评分由11.2±4.2升至23.3±4.6（P<0.05）；肾功能、肝功能及免疫抑制剂浓度在治疗前后无明显改变，无严重不良反应。结论：伐地那非联合心理疗法治疗老年男性肾移植术后ED有效且安全。

关键词: 勃起功能障碍；伐地那非；心理疗法；肾移植

Abstract:

Abstract:Objective To evaluate the efficacy and safety of vandenafil combined with mental intervention in aged male kidney transplant recipients with erectile dysfunction(ED).Methods
One hundred and twenty male patients(aged more than fifty years)who had received kidney transplantations at least one year before and whose serum creatinine was under 150 μmol·L^-1 were selected randomly in the study.Their sexual function was assessed with IIEF questionnaire,and those with ED were treated with oral vardenafil combined with mental intervention for six months.The efficacy was assessed with IIEF.Its safety was appraised by measuring serum creatinine levels,creatinine clearances,liver function and concentrations of CSA and FK506.Results Seventy-eight aged men with ED received oral vardenafil combined with mental intervention for six months.IIEF score was improved from 11.2±4.2 (before treatment)to 23.3±4.6(after treatment)（P＜0.05）;but renal function,liver function, FK506 and CSA concentrations remained unchanged.There were no significant adverse effects. Conclusion Oral vardenafil combined with mental intervention is effective and safe for the treatment of ED in aged male kidney transplant recipients.

Key words: erectile dysfunction；vardenafil;psychotherapy;kidney transplantation

中图分类号:

R698.1

洪泉, 周洪澜, 王伟刚, 傅耀文. 伐地那非联合心理疗法治疗老年男性肾移植受者勃起功能障碍的疗效评价[J]. J4, 2010, 36(1): 192-194.

HONG Quan, ZHOU Hong-Lan, WANG Wei-Gang, FU Yao-Wen. Evaluation of curative effect of vardenafil combined with mental intervention for erectile |dysfunction in aged male kidney transplant recipients[J]. J4, 2010, 36(1): 192-194.