多环芳烃不同程度污染城市人群尿中多环芳烃代谢产物水平的检测及其意义

J4 ›› 2010, Vol. 36 ›› Issue (1): 201-204.

多环芳烃不同程度污染城市人群尿中多环芳烃代谢产物水平的检测及其意义

王春华¹|吴桂锋²|杨平²|张治富²|韩春姬³|李忠民²

1. 吉林大学公共卫生学院劳动卫生与环境卫生学教研室|吉林长春 130021；2. 吉林大学公共卫生学院流行病学与卫生统计学教研室|吉林长春 130021；3. 延边大学卫生毒理学教研室,吉林延吉 133002

收稿日期:2009-04-22 出版日期:2010-01-28 发布日期:2010-01-28
通讯作者: 李忠民（Tel:0431-85619456,E-mail:lzhmin@yahoo.com） E-mail:lzhmin@yahoo.com
作者简介:王春华(1962-)|男|吉林省长春市人|实验师|主要从事环境与健康关系的研究。 
基金资助:
教育部回国人员科研启动资金资助课题（3B6051953427）

Determination of urinary PAHs metabolitesof population in polluted cities with PAHs and significance

WANG Chun-Hua¹, WU Gui-Feng², YANG Ping², ZHANG Zhi-Fu², HAN Chun-Ji³, LI Zhong-Min²

1.Department of Labor Hygiene and Environment Hygiene,School of Public Health,Jilin University,Changchun 130021,China;2.Department of Epidemiology and Health Statistics,School of Public Health,Jilin University,Changchun 130021,China;3.Department of Health Toxicology,Yanbian University,Yanji 133002,China

Received:2009-04-22 Online:2010-01-28 Published:2010-01-28

摘要/Abstract

摘要：

目的：研究多环芳烃不同程度污染城市人群尿中多环芳烃代谢产物1-羟芘葡糖苷酸（1-OHPG）和2-萘酚（2-naphthol）的水平，阐明1-OHPG和2-萘酚作为评价多环芳烃污染及对人群健康危害指标的可行性。方法：采用随机整群抽样方法，在多环芳烃（PAHs）严重污染（大同）、中等污染（长春）和较轻污染（昆明）的城市，分别对60名儿童及其家长进行问卷调查，并测定尿中多环芳烃代谢产物1-OHPG和2-萘酚的水平。结果：大同市学生尿中1-OHPG水平［（10.94±6.58） μmol·mol^-1肌酐］和家长尿中1-OHPG水平［（5.87±6.87） μmol·mol^-1肌酐］高于长春学生［(6.33±8.54） μmol·mol^-1肌酐］和家长［（4.60±4.08） μmol·mol^-1肌酐］，也高于昆明学生［（1.90±3.57） μmol·mol^-1肌酐］和家长［（1.62±2.44） μmol·mol^-1肌酐］（P<0.01），长春市学生和家长尿中1-OHPG水平高于昆明市学生和家长尿中1-OHPG水平（P<0.01）。大同、长春、昆明三城市学生之间和家长之间尿中2-萘酚水平比较差异均无显著性(P>0.05)。结论：尿中1-OHPG水平能较好地反映人群接触PAHs污染的状况，可作为评价PAHs污染对人群健康损害的生物指标。

关键词: 空气污染；生物学标记；多环芳烃；1-羟芘葡糖苷酸；2-萘酚

Abstract:

Abstract:Objective To study the levels of the population-based urinary polycyclic aromatic hydrocarbons (PAHs) metabolites, 1-hydroxypyrene glucuronide (1-OHPG) and 2-naphthol, in polluted cities with different levels of PAHs,and to clarify the feasibility of 1-OHPG and 2-naphthol as an evaluation of PAHs pollution and health hazards on the population.Methods 60 students and their parents from the three cities (Datong,Changchun and Kunming) were chosen via cluster random sampling method to fill in questionnaire and their urinary 1-OHPG and 2-naphthol levels were measured. Results The levels of urinary 1-OHPG in students （10.94 μmol·mol^-1±6.58 μmol·mol^-1creatinine）and parents （5.87 μmol·mol^-1±6.87 μmol·mol^-1creatinine）in Datong were higher than those in Changchun (students:6.33 μmol?mol-1±8.54 μmol?mol-1 creatinine;parents:4.60 μmol·mol^-1±4.08 μmol·mol^-1creatinine）and Kunming (students:1.90 ·mol^-1±3.57 μmol·mol^-1creatinine;parents:1.62 μmol·mol^-1±2.44 μmol·mol^-1creatinine）（P<0.01）.The levels of urinary 1-OHPG in students and parents in Changchun were higher than those in Kunming(P<0.01).Moreover,in the children and their parents,there were no significant differences of the urinary 2-naphthol levels 　between three cities（P>0.05）. Conclusion The urinary 1-OHPG level could proper
ly represent the pollution condition of PAHs.It could be used as a biomarker to evaluate the population harm of PAHs pollution.

Key words: air pollution;biological markers;polycyclic aromatic hydrocarbons;1-hydroxyprene glucuronide;2-naphthol

中图分类号:

R181.3

王春华, 吴桂锋, 杨平, 张治富, 韩春姬, 李忠民. 多环芳烃不同程度污染城市人群尿中多环芳烃代谢产物水平的检测及其意义[J]. J4, 2010, 36(1): 201-204.

WANG Chun-Hua, WU Gui-Feng, YANG Ping, ZHANG Zhi-Fu, HAN Chun-Ji, LI Zhong-Min. Determination of urinary PAHs metabolitesof population in polluted cities with PAHs and significance[J]. J4, 2010, 36(1): 201-204.