关键词: 宫颈肿瘤；基质金属蛋白酶-9；基质金属蛋白酶-26；基质金属蛋白酶组织抑制因子-4

Abstract:

Abstract:Objective To detect the expressions of matrix metalloproteinase-26 (MMP-26),metalloproteinase-9 (MMP-9) and tissue inhibitors of metalloproteinase-4 (TIMP-4) in the cervical carcinoma tissues and analyze their correlation with clinical features.Methods The expressions of MMP-26,MMP-9 and TIMP-4 were detected in 10 cases of normal cervical tissues,6 cases of cervical carcinoma in situ and 79 cases of invasive carcinoma of cervix by immunohistochemistry.Results MMP-26 showed strongly positive staining in cervical carcinoma in situ and invasive carcinoma of cervix,their positive rates were 83.33% and 82.47%, respectively;there were significant differences compared with normal cervix (P<0.05).The expression of MMP-26 was closely correlated with the depth of myometrial invasion and lymph node metastasis(P<0.05).The positive rate of MMP-9 in cervival carcinoma tissue was 68.35%.The expression of MMP-9 was strongly correlated with pathological grading,its expression in grade Ⅲ was significantly higher than those in grade Ⅰ and Ⅱ（P<0.05）.The expression of TIMP-4 gradually decreased from normal cervical tissue to carcinoma in situ and invasive carcinoma,but no significant difference（P>0.05）.The expression of TIMP-4 was strongly correlated with clinical stage,its expression in early stage was significantly higher than that in late stage（P<0.05）.The expression of MMP-26 showed negative correlation with TIMP-4（r_s=－0.259,P<0.05）,while there was no correlation between MMP-26 and MMP-9（r_s=0.140,P>0.05）.Conclusion The expressions of MMP-26,MMP-9 are increased in cervix carcinoma tissue.They promote the local invasion and metastasis of cervix carcinoma tissue .The expression of TIMP-4 is decreased in cervix carcinoma tissue.Their application together could be a marker to monitor the prognosis of vervical carcinoma tissue.

Key words: uterine cervical neoplasms;matrix metalloproteinase-9;matrix metalloproteinase-26;tissue inhibitors of metalloproteinase-4