关键词: 冠心病/遗传学；脂蛋白脂酶；Meta-分析

Abstract:

Abstract:Objective To evaluate the relationship between the polymorphism of lipoprotein lipase(LPL) PvuⅡP-P-genetype and coronary heart disease (CHD) in Chinese Han population,and expound the function of LPL PvuⅡP-P-genetype in occurrence and development of CHD.Methods According to the requirements of Cochrane systematic review,a thorough literature search about studies on the relationship between the polymorphism of LPL PvuⅡ and CHD was performed among PubMed,Medline,Chinese periodical full text database,Wanfang datebase and Vip information database.The qualities of documents were evaluated.RevMan 5.0 software was used to perform the Meta-analysis on those valid studies.Results Six literatures met the inclusion criteria,including 593 patients and 572 controls.The distribution of LPL PvuⅡgenotype of both groups in every study was in accordance with Hardy-Weinberg equilibrium.No heterogeneity was found between the six studies,nor the statistical publication bias.With the M-H mathematical model,the pooled odds ratio for PvuⅡP-P-/(P-P+/P+P+) in CHD group against control group was 2.32,95%CI(1.64,3.28),P<0.05.The funnel plots was symmetrical,which means there was no publish bias between the six studies.Conclusion Chinese Han population who carries the LPL P-P-genotype has a higher risk to be subjects of CHD,which suggests that the LPL P-P-genotype may be the susceptibility gene of CHD.

Key words: coronary disease /genetics;lipoprotein lipase;Meta-analysis