胰岛素样生长因子受体1在乳腺癌组织中的表达及意义

J4 ›› 2010, Vol. 36 ›› Issue (3): 550-553.

胰岛素样生长因子受体1在乳腺癌组织中的表达及意义

宋东¹ 韩冰¹ 乔伟松² 付彤¹ 于凌云¹ 侯鑫磊¹

（1.吉林大学第一医院乳腺外科|吉林长春 130021；2.吉林大学第一医院骨科|吉林长春 130021）

收稿日期:2009-01-16 出版日期:2010-05-28 发布日期:2010-05-28
通讯作者: 付彤 E-mail:ftdavid@126.com
作者简介:宋东（1969-）|女|吉林省长春市人|副教授|副主任医师|医学博士|主要从事乳腺癌信号传导通路与内分泌系统的交联研究。
基金资助:
吉林省科技厅科技发展计划项目资助课题（20071133）

Expression of insulin-like growth factor receptor 1 in breast cancer |and its clinical significance

SONG Dong¹ HAN Bing¹ JIAO Wei-Song² FU Tong¹ XU Ling-Yun¹ HOU Xin-Lei¹

(1.Department of Breast Surgery,First Hospital| Jilin University,Changchun 130021|China；2.Department of Orthopedics,First Hospital,Jilin University,Changchun 130021,China)

Received:2009-01-16 Online:2010-05-28 Published:2010-05-28

摘要/Abstract

摘要：

目的：探讨胰岛素样生长因子受体1（IGFR-1）在乳腺良、恶性疾病组织中的表达及与各临床参数的关系。方法：采用免疫组织化学法检测IGFR-1在34例乳腺浸润性导管癌和28例乳腺良性疾病组织中的表达率。结果：IGFR-1在乳腺癌组织中的表达率为76.5%，明显高于其在良性乳腺疾病组织中的表达率44.1%（P<0.05）；IGFR-1在乳腺癌组织中的表达水平与雌激素受体（ER）、孕激素受体（PR）呈正相关（r=0.56，P<0.01；r=0.51，P<0.01）；与腋下淋巴结转移及临床分期无关（r=0.31，P>0.05；r=0.18，P>0.05）。结论：在大多数乳腺癌组织中表达的IGFR-1可作为标志物用于肿瘤的诊断和预后判断，并可作为乳腺癌靶向治疗的新靶点。

关键词: 乳腺肿瘤；胰岛素样生长因子；免疫组织化学

Abstract:

Abstract:Objective
To examine the expression of insulin-like growth factor receptor 1（IGFR-1） in breast cancer tissue and its relationship with clinical parameters. Methods The expressions of IGFR-1 were detected in paraffin-embedded specimens from 34 patients with breast cancer and 28 controls with surgically proven benign breast disease with immunohistochemical method. Results The expression rate of IGFR-1 in breast cancer tissue was 76.5%,it was significantly higher than that in benign tissue (44.1%)（P<0.05）.In cancer group,there was positive correlation between the expression level of IGFR-1 and estrogen receptor (ER) and progesterone receptor (PR) (r=0.56,r=0.51,P<0.01);there was no significant relationship between IGFR-1 expression and armpit lymphatic node metastasis and clinical stages (r=0.31,r=0.18,both P>0.05).Conclusion IGFR-1 can express in most of the breast cancer tissues which could be used as a biomarker for diagnosis and prognosis of breast cancer and a new target for treatment of breast cancer.

Key words: breast neoplasms;insulin-like growth factors;immunohistology

中图分类号:

R737.9

宋东, 韩冰, 乔伟松, 付彤, 于凌云, 侯鑫磊. 胰岛素样生长因子受体1在乳腺癌组织中的表达及意义[J]. J4, 2010, 36(3): 550-553.

SONG Dong, HAN Bing, JIAO Wei-Song, FU Tong, XU Ling-Yun, HOU Xin-Lei. Expression of insulin-like growth factor receptor 1 in breast cancer |and its clinical significance[J]. J4, 2010, 36(3): 550-553.